TLX3

Protein-coding gene in the species Homo sapiens
TLX3
Identifiers
AliasesTLX3, HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3
External IDsOMIM: 604640 MGI: 1351209 HomoloGene: 23181 GeneCards: TLX3
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TLX3
Genomic location for TLX3
Band5q35.1Start171,309,248 bp[1]
End171,312,139 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TLX3
Genomic location for TLX3
Band11|11 A4Start33,150,752 bp[2]
End33,153,589 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pituitary gland

  • anterior pituitary

  • female reproductive system

  • oviduct

  • integument

  • zone of skin

  • vagina

  • limb

  • leg

  • dorsolateral prefrontal cortex
Top expressed in
  • urethra

  • female urethra

  • male urethra

  • neural tube

  • enteric nervous system

  • trigeminal ganglion

  • meninges

  • mesencephalon

  • inner ear

  • ventricular system
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • sequence-specific DNA binding
  • DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • multicellular organism development
  • regulation of respiratory gaseous exchange by nervous system process
  • cell fate specification
  • neuron fate specification
  • central nervous system development
  • neuron migration
  • regulation of transcription, DNA-templated
  • negative regulation of neuron differentiation
  • respiratory gaseous exchange by respiratory system
  • neuron differentiation
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

30012

27140

Ensembl

ENSG00000164438

ENSMUSG00000040610

UniProt

O43711

O55144

RefSeq (mRNA)

NM_021025

NM_019916

RefSeq (protein)

NP_066305

NP_064300

Location (UCSC)Chr 5: 171.31 – 171.31 MbChr 11: 33.15 – 33.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.[5][6][7]

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164438 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040610 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (3–4): 358. doi:10.1159/000056933. PMID 11435718. S2CID 85323468.
  6. ^ Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet. 92 (3–4): 354–5. doi:10.1159/000056931. PMID 11435716. S2CID 35224759.
  7. ^ a b "Entrez Gene: TLX3 T-cell leukemia homeobox 3".

Further reading

  • Dear TN, Sanchez-Garcia I, Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4431–5. doi:10.1073/pnas.90.10.4431. PMC 46525. PMID 8099440.
  • Bernard OA, Busson-LeConiat M, Ballerini P, et al. (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia". Leukemia. 15 (10): 1495–504. doi:10.1038/sj.leu.2402249. PMID 11587205. S2CID 32493784.
  • Ballerini P, Blaise A, Busson-Le Coniat M, et al. (2002). "HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis". Blood. 100 (3): 991–7. doi:10.1182/blood-2001-11-0093. PMID 12130513. S2CID 16589332.
  • Matera I, Bachetti T, Cinti R, et al. (2003). "Mutational analysis of the RNX gene in congenital central hypoventilation syndrome". Am. J. Med. Genet. 113 (2): 178–82. doi:10.1002/ajmg.10746. PMID 12407709.
  • Mauvieux L, Leymarie V, Helias C, et al. (2003). "High incidence of Hox11L2 expression in children with T-ALL". Leukemia. 16 (12): 2417–22. doi:10.1038/sj.leu.2402709. PMID 12454747. S2CID 20611777.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Berger R, Dastugue N, Busson M, et al. (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)". Leukemia. 17 (9): 1851–7. doi:10.1038/sj.leu.2403061. PMID 12970786. S2CID 24379766.
  • Cavé H, Suciu S, Preudhomme C, et al. (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. 103 (2): 442–50. doi:10.1182/blood-2003-05-1495. PMID 14504110.
  • Su XY, Busson M, Della Valle V, et al. (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia". Genes Chromosomes Cancer. 41 (3): 243–9. doi:10.1002/gcc.20088. PMID 15334547. S2CID 19782389.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ballerini P, Busson M, Fasola S, et al. (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance". Leukemia. 19 (3): 468–70. doi:10.1038/sj.leu.2403654. PMID 15674415. S2CID 27045652.
  • Gottardo NG, Jacoby PA, Sather HN, et al. (2005). "Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols". Leukemia. 19 (9): 1705–8. doi:10.1038/sj.leu.2403834. PMID 15990867.
  • Borghini S, Vargiolu M, Di Duca M, et al. (2006). "Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia". Mol. Cancer Res. 4 (9): 635–43. doi:10.1158/1541-7786.MCR-05-0250. PMID 16966433.
  • Nagel S, Scherr M, Kel A, et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Res. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.
  • v
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  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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