TRAPPC3

Protein-coding gene in the species Homo sapiens
TRAPPC3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1SZ7, 2C0J, 2CFH, 3KXC

Identifiers
AliasesTRAPPC3, BET3, trafficking protein particle complex 3, trafficking protein particle complex subunit 3
External IDsOMIM: 610955; MGI: 1351486; HomoloGene: 6399; GeneCards: TRAPPC3; OMA:TRAPPC3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TRAPPC3
Genomic location for TRAPPC3
Band1p34.3Start36,136,570 bp[1]
End36,156,053 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TRAPPC3
Genomic location for TRAPPC3
Band4|4 D2.2Start126,156,118 bp[2]
End126,169,676 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal gland

  • left adrenal gland

  • right lobe of thyroid gland

  • islet of Langerhans

  • left lobe of thyroid gland

  • right coronary artery

  • anterior pituitary

  • thoracic aorta

  • ascending aorta

  • monocyte
Top expressed in
  • calvaria

  • medial ganglionic eminence

  • cerebellar cortex

  • choroid plexus

  • lip

  • yolk sac

  • cerebellar vermis

  • superior frontal gyrus

  • secondary oocyte

  • vas deferens
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • Golgi apparatus
  • endoplasmic reticulum
  • Golgi membrane
  • cytosol
  • TRAPP complex
  • cis-Golgi network membrane
Biological process
  • COPII vesicle coating
  • vesicle-mediated transport
  • Golgi vesicle transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • intra-Golgi vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27095

27096

Ensembl

ENSG00000054116

ENSMUSG00000028847

UniProt

O43617

O55013

RefSeq (mRNA)

NM_001270894
NM_001270895
NM_001270896
NM_001270897
NM_014408

NM_013718

RefSeq (protein)

NP_001257823
NP_001257824
NP_001257825
NP_001257826
NP_055223

NP_038746

Location (UCSC)Chr 1: 36.14 – 36.16 MbChr 4: 126.16 – 126.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trafficking protein particle complex subunit 3 is a protein that in humans is encoded by the TRAPPC3 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000054116 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028847 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. ^ "Entrez Gene: TRAPPC3 trafficking protein particle complex 3".

Further reading

  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Sacher M, Jiang Y, Barrowman J, et al. (1998). "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion". EMBO J. 17 (9): 2494–503. doi:10.1093/emboj/17.9.2494. PMC 1170591. PMID 9564032.
  • Barrowman J, Sacher M, Ferro-Novick S (2000). "TRAPP stably associates with the Golgi and is required for vesicle docking". EMBO J. 19 (5): 862–9. doi:10.1093/emboj/19.5.862. PMC 305626. PMID 10698928.
  • Gavin AC, Bösche M, Krause R, et al. (2002). "Functional organization of the yeast proteome by systematic analysis of protein complexes". Nature. 415 (6868): 141–7. Bibcode:2002Natur.415..141G. doi:10.1038/415141a. PMID 11805826. S2CID 4425555.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kim YG, Sohn EJ, Seo J, et al. (2005). "Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP". Nat. Struct. Mol. Biol. 12 (1): 38–45. doi:10.1038/nsmb871. PMID 15608655. S2CID 22597154.
  • Turnbull AP, Kümmel D, Prinz B, et al. (2005). "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization". EMBO J. 24 (5): 875–84. doi:10.1038/sj.emboj.7600565. PMC 554119. PMID 15692564.
  • Loh E, Peter F, Subramaniam VN, Hong W (2005). "Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus" (PDF). J. Cell Sci. 118 (Pt 6): 1209–22. doi:10.1242/jcs.01723. PMID 15728249. S2CID 3092909.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kim MS, Yi MJ, Lee KH, et al. (2006). "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p". Traffic. 6 (12): 1183–95. doi:10.1111/j.1600-0854.2005.00352.x. PMID 16262728. S2CID 24273412.
  • Kümmel D, Müller JJ, Roske Y, et al. (2006). "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2". J. Mol. Biol. 361 (1): 22–32. doi:10.1016/j.jmb.2006.06.012. PMID 16828797.
  • Yu S, Satoh A, Pypaert M, et al. (2006). "mBet3p is required for homotypic COPII vesicle tethering in mammalian cells". J. Cell Biol. 174 (3): 359–68. doi:10.1083/jcb.200603044. PMC 2064232. PMID 16880271.
  • Kümmel D, Heinemann U, Veit M (2006). "Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability". Proc. Natl. Acad. Sci. U.S.A. 103 (34): 12701–6. Bibcode:2006PNAS..10312701K. doi:10.1073/pnas.0603513103. PMC 1562543. PMID 16908848.
  • v
  • t
  • e
  • 1sz7: Crystal structure of Human Bet3
    1sz7: Crystal structure of Human Bet3
  • 1wc8: THE CRYSTAL STRUCTURE OF MOUSE BET3P
    1wc8: THE CRYSTAL STRUCTURE OF MOUSE BET3P
  • 1wc9: THE CRYSTAL STRUCTURE OF TRUNCATED MOUSE BET3P
    1wc9: THE CRYSTAL STRUCTURE OF TRUNCATED MOUSE BET3P
  • 2c0j: CRYSTAL STRUCTURE OF THE BET3-TRS33 HETERODIMER
    2c0j: CRYSTAL STRUCTURE OF THE BET3-TRS33 HETERODIMER
  • 2cfh: STRUCTURE OF THE BET3-TPC6B CORE OF TRAPP
    2cfh: STRUCTURE OF THE BET3-TPC6B CORE OF TRAPP
  • 2j3r: THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.
    2j3r: THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.
  • 2j3t: THE CRYSTAL STRUCTURE OF THE BET3-TRS33-BET5-TRS23 COMPLEX.
    2j3t: THE CRYSTAL STRUCTURE OF THE BET3-TRS33-BET5-TRS23 COMPLEX.
  • 2j3w: THE CRYSTAL STRUCTURE OF THE BET3-TRS31-SEDLIN COMPLEX.
    2j3w: THE CRYSTAL STRUCTURE OF THE BET3-TRS31-SEDLIN COMPLEX.
  • 2pwn: Crystal structure of BET3 homolog (13277653) from Mus musculus at 2.04 A resolution
    2pwn: Crystal structure of BET3 homolog (13277653) from Mus musculus at 2.04 A resolution
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