TRERF1

Protein-coding gene in the species Homo sapiens
TRERF1
Identifiers
AliasesTRERF1, BCAR2, HSA277276, RAPA, TREP132, TReP-132, dJ139D8.5, transcriptional regulating factor 1
External IDsOMIM: 610322 MGI: 2442086 HomoloGene: 14129 GeneCards: TRERF1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TRERF1
Genomic location for TRERF1
Band6p21.1Start42,224,931 bp[1]
End42,452,051 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for TRERF1
Genomic location for TRERF1
Band17|17 CStart47,451,801 bp[2]
End47,672,883 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • parietal pleura

  • middle temporal gyrus

  • blood

  • pancreatic ductal cell

  • gums

  • bronchial epithelial cell

  • stromal cell of endometrium

  • oral cavity

  • urinary bladder
Top expressed in
  • nucleus accumbens

  • olfactory tubercle

  • temporal lobe

  • medullary collecting duct

  • substantia nigra

  • amygdala

  • vas deferens

  • renal corpuscle

  • trigeminal ganglion

  • cumulus cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • metal ion binding
  • transcription coregulator activity
  • DNA binding
  • DNA binding, bending
  • nuclear receptor coactivator activity
  • transcription factor binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • histone deacetylase complex
  • transcription regulator complex
  • nucleoplasm
  • nucleolus
  • cytosol
Biological process
  • multicellular organism development
  • cholesterol catabolic process
  • regulation of transcription, DNA-templated
  • homeostatic process
  • steroid biosynthetic process
  • positive regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of hormone biosynthetic process
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55809

224829

Ensembl

ENSG00000124496

ENSMUSG00000064043

UniProt

Q96PN7

Q8BXJ2

RefSeq (mRNA)
NM_001297573
NM_018415
NM_033501
NM_033502
NM_001391983

NM_001391984
NM_001395490

NM_001097623
NM_172622

RefSeq (protein)

NP_001284502
NP_277037

NP_001091092
NP_766210

Location (UCSC)Chr 6: 42.22 – 42.45 MbChr 17: 47.45 – 47.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.[5][6]

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.[6]

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,[7] EP300[5] and CREB-binding protein.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124496 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064043 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Gizard F, Lavallée B, DeWitte F, Hum DW (September 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". The Journal of Biological Chemistry. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.
  6. ^ a b "Entrez Gene: TRERF1 transcriptional regulating factor 1".
  7. ^ Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of Biological Chemistry. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.

Further reading

  • Dorssers LC, Veldscholte J (August 1997). "Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells". International Journal of Cancer. 72 (4): 700–5. doi:10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D. PMID 9259413. S2CID 29607511.
  • Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of Biological Chemistry. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.
  • Gizard F, El-Alfy M, Duguay Y, Lavallée B, DeWitte F, Staels B, et al. (November 2002). "Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression". Endocrine Research. 28 (4): 559–74. doi:10.1081/ERC-120016841. PMID 12530663. S2CID 22485023.
  • Gizard F, Teissier E, Dufort I, Luc G, Luu-The V, Staels B, Hum DW (April 2004). "The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells". Journal of Molecular Endocrinology. 32 (2): 557–69. doi:10.1677/jme.0.0320557. PMID 15072559.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gizard F, Robillard R, Barbier O, Quatannens B, Faucompré A, Révillion F, et al. (June 2005). "TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1". Molecular and Cellular Biology. 25 (11): 4335–48. doi:10.1128/MCB.25.11.4335-4348.2005. PMC 1140623. PMID 15899840.
  • Gizard F, Robillard R, Gross B, Barbier O, Révillion F, Peyrat JP, et al. (October 2006). "TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone". Molecular and Cellular Biology. 26 (20): 7632–44. doi:10.1128/MCB.00326-06. PMC 1636875. PMID 17015480.


  • v
  • t
  • e