TSPY1

Protein-coding gene in humans
TSPY1
Identifiers
AliasesTSPY1, CT78, DYS14, TSPY, pJA923, testis specific protein, Y-linked 1, testis specific protein Y-linked 1
External IDsOMIM: 480100 HomoloGene: 87844 GeneCards: TSPY1
Gene location (Human)
Y chromosome (human)
Chr.Y chromosome (human)[1]
Y chromosome (human)
Genomic location for TSPY1
Genomic location for TSPY1
BandYp11.2Start9,466,955 bp[1]
End9,469,749 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • multicellular organism

  • heart

  • renal cortex

  • brain

  • adipose tissue

  • blood

  • gallbladder
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • cytoplasm
  • nucleus
  • cellular component
Biological process
  • multicellular organism development
  • nucleosome assembly
  • cell differentiation
  • cell population proliferation
  • sex differentiation
  • spermatogenesis
  • gonadal mesoderm development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7258

n/a

Ensembl

ENSG00000258992

n/a

UniProt

Q01534

n/a

RefSeq (mRNA)

NM_003308
NM_001197242
NM_001320964

n/a

RefSeq (protein)

NP_001184171
NP_001307893
NP_003299

n/a

Location (UCSC)Chr Y: 9.47 – 9.47 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Testis-specific Y-encoded protein 1 is a protein that in humans is encoded by the TSPY1 gene.[3]

The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional orthologous gene is found in mice. Two transcript variants encoding different isoforms have been found for this gene.[4] The protein is strongly overexpressed in gonadoblastoma.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000258992 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: TSPY1 Testis specific protein, Y-linked 1".
  4. ^ "TSPY1 testis specific protein Y-linked 1 [Homo sapiens (human)] - Gene - NCBI".
  5. ^ Schnieders F, Dörk T, Arnemann J, et al. (1997). "Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues". Hum. Mol. Genet. 5 (11): 1801–7. doi:10.1093/hmg/5.11.1801. PMID 8923009.

Further reading

  • Chandley AC, Cooke HJ (1995). "Human male fertility--Y-linked genes and spermatogenesis". Hum. Mol. Genet. 3. Spec No: 1449–52. doi:10.1093/hmg/3.suppl_1.1449. PMID 7849736.
  • Vogel T, Schmidtke J (1998). "Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein"". Cytogenet. Cell Genet. 80 (1–4): 209–13. doi:10.1159/000014982. PMID 9678360. S2CID 46875273.
  • Lau YF (2000). "Gonadoblastoma, testicular and prostate cancers, and the TSPY gene". Am. J. Hum. Genet. 64 (4): 921–7. doi:10.1086/302353. PMC 1377814. PMID 10090875.
  • Zhang JS, Yang-Feng TL, Muller U, et al. (1993). "Molecular isolation and characterization of an expressed gene from the human Y chromosome". Hum. Mol. Genet. 1 (9): 717–26. doi:10.1093/hmg/1.9.717. PMID 1284595.
  • Arnemann J, Jakubiczka S, Thüring S, Schmidtke J (1992). "Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY". Genomics. 11 (1): 108–14. doi:10.1016/0888-7543(91)90107-P. PMID 1765369.
  • Arnemann J, Epplen JT, Cooke HJ, et al. (1988). "A human Y-chromosomal DNA sequence expressed in testicular tissue". Nucleic Acids Res. 15 (21): 8713–24. doi:10.1093/nar/15.21.8713. PMC 306400. PMID 3479749.
  • Manz E, Schnieders F, Brechlin AM, Schmidtke J (1993). "TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome". Genomics. 17 (3): 726–31. doi:10.1006/geno.1993.1393. PMID 8244388.
  • Kim HS, Takenaka O (1996). "A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogeny". Am. J. Phys. Anthropol. 100 (3): 301–9. doi:10.1002/(SICI)1096-8644(199607)100:3<301::AID-AJPA1>3.0.CO;2-X. PMID 8798990.
  • Vogt PH, Affara N, Davey P, et al. (1998). "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997". Cytogenet. Cell Genet. 79 (1–2): 1–20. doi:10.1159/000134680. PMID 9533010.
  • Vogel T, Dittrich O, Mehraein Y, et al. (1998). "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family". Cytogenet. Cell Genet. 81 (3–4): 265–70. doi:10.1159/000015042. PMID 9730615. S2CID 46829106.
  • Lau YF, Zhang J (2000). "Expression analysis of thirty one Y chromosome genes in human prostate cancer". Mol. Carcinog. 27 (4): 308–21. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R. PMID 10747295. S2CID 23677925.
  • Ratti A, Stuppia L, Gatta V, et al. (2000). "Characterization of a new TSPY gene family member in Yq (TSPYq1)". Cytogenet. Cell Genet. 88 (1–2): 159–62. doi:10.1159/000015510. PMID 10773691. S2CID 20806022.
  • Dechend F, Williams G, Skawran B, et al. (2001). "TSPY variants in six loci on the human Y chromosome". Cytogenet. Cell Genet. 91 (1–4): 67–71. doi:10.1159/000056821. PMID 11173833. S2CID 21757455.
  • Lau Y, Chou P, Iezzoni J, et al. (2001). "Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma". Cytogenet. Cell Genet. 91 (1–4): 160–4. doi:10.1159/000056838. PMID 11173850. S2CID 34017469.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Krick R, Jakubiczka S, Arnemann J (2003). "Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes". Gene. 302 (1–2): 11–9. doi:10.1016/S0378-1119(02)01104-6. PMID 12527192.
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