Talsupram

Chemical compound
  • none
Legal statusLegal status
  • In general: uncontrolled
Identifiers
  • 3-(3,3-dimethyl-1-phenyl-2-benzothiophen-1-yl)-N-methyl-propan-1-amine
CAS Number
  • 21489-20-3
PubChem CID
  • 33014
ChemSpider
  • 30557
UNII
  • C6Z73MW6CR
Chemical and physical dataFormulaC20H25NSMolar mass311.49 g·mol−1

Talsupram (Lu 5-005 or Lu 5-003[1]) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.[2][3][4] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[5]

See also

  • Talopram

References

  1. ^ Carlsson A, Fuxe K, Hamberger B, Malmfors T (May 1969). "Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro". British Journal of Pharmacology. 36 (1): 18–28. doi:10.1111/j.1476-5381.1969.tb08299.x. ISSN 0007-1188. OCLC 6895508396. PMC 1703539. PMID 5768100.
  2. ^ Pawłowski L, Mazela H (June 1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology. 88 (2): 240–246. doi:10.1007/BF00652248. ISSN 0033-3158. OCLC 5653283278. PMID 3006113. S2CID 1732297.
  3. ^ McConathy J, Owens MJ, Kilts CD, et al. (August 2004). "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology. 31 (6): 705–18. doi:10.1016/j.nucmedbio.2003.05.001. PMID 15246361.
  4. ^ Kelliher P, Kelly JP, Leonard BE, Sánchez C (April 2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology. 28 (3): 332–47. doi:10.1016/S0306-4530(02)00026-4. PMID 12573300. S2CID 23452713.
  5. ^ "The SSRI Issues" (DOC). healyprozac.com. Retrieved January 3, 2024.
  • v
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Antidepressants (N06A)
Specific reuptake inhibitors and/or receptor modulators
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Miscellaneous
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  • e
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins


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