Tampramine

Chemical compound
  • In general: uncontrolled
Identifiers
  • N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine
CAS Number
  • 83166-17-0
    83166-18-1 (fumarate)
PubChem CID
  • 54961
ChemSpider
  • 49631
UNII
  • 47GSE5RM8N
CompTox Dashboard (EPA)
  • DTXSID00232203 Edit this at Wikidata
Chemical and physical dataFormulaC23H24N4Molar mass356.473 g·mol−13D model (JSmol)
  • Interactive image
  • CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]

See also

  • Tricyclic antidepressant

References

  1. ^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology. 33 (19): 3001–5. doi:10.1016/0006-2952(84)90600-2. PMID 6548381.
  2. ^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology. 87 (3): 283–5. doi:10.1007/BF00432708. PMID 3936083. S2CID 20677730.
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Antidepressants (N06A)
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Miscellaneous
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α1
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α2
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β
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  • See also: Receptor/signaling modulators
  • Dopaminergics
  • Serotonergics
  • Monoamine reuptake inhibitors
  • Monoamine releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
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Classes
Antidepressants
(Tricyclic antidepressants (TCAs))
Antihistamines
Antipsychotics
Anticonvulsants
Anticholinergics
Others