Testicular receptor 2

Human protein-coding gene
NR2C1
Identifiers
AliasesNR2C1, TR2, Testicular receptor 2, nuclear receptor subfamily 2 group C member 1
External IDsOMIM: 601529 MGI: 1352465 HomoloGene: 55731 GeneCards: NR2C1
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NR2C1
Genomic location for NR2C1
Band12q22Start95,020,229 bp[1]
End95,073,628 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for NR2C1
Genomic location for NR2C1
Band10 C2|10 48.81 cMStart93,983,885 bp[2]
End94,033,073 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • left lobe of thyroid gland

  • right lung

  • tibial nerve

  • sural nerve

  • right lobe of thyroid gland

  • right lobe of liver

  • gastric mucosa

  • canal of the cervix

  • right uterine tube
Top expressed in
  • spermatid

  • spermatocyte

  • seminal vesicula

  • corneal stroma

  • male urethra

  • secondary oocyte

  • seminiferous tubule

  • wall of urinary bladder

  • mucosa of urinary bladder

  • left lobe of liver
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • sequence-specific DNA binding
  • protein homodimerization activity
  • DNA-binding transcription factor activity
  • zinc ion binding
  • histone deacetylase binding
  • metal ion binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • steroid hormone receptor activity
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • protein binding
  • DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • signaling receptor activity
Cellular component
  • PML body
  • nucleoplasm
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • positive regulation of retinoic acid receptor signaling pathway
  • transcription initiation from RNA polymerase II promoter
  • negative regulation of transcription, DNA-templated
  • steroid hormone mediated signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7181

22025

Ensembl

ENSG00000120798

ENSMUSG00000005897

UniProt

P13056

Q505F1

RefSeq (mRNA)

NM_001032287
NM_001127362
NM_003297

NM_011629

RefSeq (protein)

NP_001027458
NP_001120834
NP_003288
NP_003288.2

NP_035759

Location (UCSC)Chr 12: 95.02 – 95.07 MbChr 10: 93.98 – 94.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.[5][6] TR2 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 2 has been shown to interact with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120798 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005897 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
  6. ^ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
  7. ^ Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. S2CID 24134119.
  8. ^ Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
  9. ^ Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
  10. ^ a b Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. S2CID 19487189.
  11. ^ a b Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.

Further reading

  • Chang C, Kokontis J (Sep 1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis". Biochemical and Biophysical Research Communications. 155 (2): 971–7. doi:10.1016/S0006-291X(88)80591-6. PMID 3421977.
  • Lin DL, Wu SQ, Chang C (Apr 1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily". Endocrine. 8 (2): 123–34. doi:10.1385/ENDO:8:2:123. PMID 9704569. S2CID 23712655.
  • Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". The Journal of Biological Chemistry. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.
  • Lee CH, Chinpaisal C, Wei LN (Nov 1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2". Molecular and Cellular Biology. 18 (11): 6745–55. doi:10.1128/mcb.18.11.6745. PMC 109258. PMID 9774688.
  • Yu Z, Lee CH, Chinpaisal C, Wei LN (Oct 1998). "A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2". The Journal of Endocrinology. 159 (1): 53–60. doi:10.1677/joe.0.1590053. PMID 9795341.
  • Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.
  • Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO Journal. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC 126089. PMID 12093744.
  • Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
  • Inui S, Lee YF, Chang E, Shyr CR, Chang C (Feb 2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
  • Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. S2CID 19487189.
  • Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. S2CID 24134119.
  • Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
  • Lin YL, Wang YH, Lee HJ (Nov 2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.
  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies