Thiorphan
Chemical compound
- none
- (±)-2-[(2-benzyl-3-sulfanyl-propanoyl)amino]acetic acid
- 76721-89-6
N
- 3132
- DB08626 N
- 3020
Y
- B79L7B5X3Z
- C01619
- ChEMBL10247 Y
- Interactive image
- C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O
InChI
- InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)Y
- Key:LJJKNPQAGWVLDQ-UHFFFAOYSA-NY
N
Y (what is this?) (verify)Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan).[1] It prevents the degradation of endogenous enkephalins by acting as an enkephalinase inhibitor.[1][2]
References
- ^ a b Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (June 1986). "In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF". European Journal of Pharmacology. 125 (1): 147–50. doi:10.1016/0014-2999(86)90094-4. PMID 3015640.
- ^ Matheson AJ, Noble S (April 2000). "Racecadotril". Drugs. 59 (4): 829–35, discussion 836–7. doi:10.2165/00003495-200059040-00010. PMID 10804038. S2CID 245710392.
- v
- t
- e
- Sulfonamides
- Charcoal
- Bismuth (including bismuth subsalicylate, known as Pepto-Bismol)
- Pectin
- Kaolin
- Crospovidone
- Attapulgite
- Diosmectite
- Opium tincture (laudanum)
- Codeine
- Morphine
- Camphorated opium tincture (paregoric)
- crosses BBB: Diphenoxylate (+atropine)
- Difenoxin
- does not cross BBB: Eluxadoline
- Loperamide# (+simethicone)
- corticosteroids acting locally
- antiallergic agents, excluding corticosteroids
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
 | This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e
