Timepidium bromide

Chemical compound
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  • A03AB19 (WHO)
Legal statusLegal status
  • In general: ℞ (Prescription only)
Identifiers
IUPAC name
  • 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethylpiperidinium bromide
CAS Number
  • 35035-05-3 checkY
PubChem CID
  • 160243
ChemSpider
  • 140841 ☒N
UNII
  • 8R9E4766V4
CompTox Dashboard (EPA)
  • DTXSID4023672 Edit this at Wikidata
Chemical and physical dataFormulaC17H22BrNOS2Molar mass400.39 g·mol−13D model (JSmol)
  • Interactive image
SMILES
  • C[N+]1(CC(CC(=C(C2=CC=CS2)C3=CC=CS3)C1)OC)C.[Br-]
InChI
  • InChI=1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1 ☒N
  • Key:QTSXMEPZSHLZFF-UHFFFAOYSA-M ☒N
 ☒NcheckY (what is this?)  (verify)

Timepidium bromide (INN) is an anticholinergic. It is used in the symptomatic treatment of visceral spasms.[1] It is also used to relieve pain associated with various gastrointestinal disorders.[2] The quaternary nitrogen prevents it from crossing the blood brain barrier, so it is peripherally acting with no central side effects.

The same compound sans the quaternary methyl group and the methoxy ether is called tipepidine.[3]

References

  1. ^ "Timepidium bromide: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia". www.mims.com. Retrieved 2021-07-05.
  2. ^ "Timepidium Bromide Tablets 30mg SAWAI 100 Tablets|Natural Pharmacy". www.mimaki-family-japan.com. Retrieved 2021-07-05.
  3. ^ Shah R, Verma PK (December 2018). "Therapeutic importance of synthetic thiophene". Chemistry Central Journal. 12 (1): 137. doi:10.1186/s13065-018-0511-5. PMC 6768136. PMID 30564984.
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Drugs for functional gastrointestinal disorders (A03)
Drugs for
functional
bowel
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Antimuscarinics
Tertiary
amino group
Quaternary
ammonium
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mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators


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