Tinidazole

Pregnancy
categoryRoutes of
administrationBy mouthATC codeLegal statusLegal status Pharmacokinetic dataProtein binding12%MetabolismLiver (CYP3A4)Elimination half-life12–14 hoursExcretionUrine (20–25%), feces (12%)IdentifiersCAS NumberPubChem CIDDrugBankChemSpiderUNIIKEGGChEMBLNIAID ChemDBCompTox Dashboard (EPA)ECHA InfoCard100.039.089 Chemical and physical dataFormulaC₈H₁₃N₃O₄SMolar mass247.27 g·mol⁻¹3D model (JSmol)  (verify)

Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.^[2]

It is on the World Health Organization's List of Essential Medicines.^[3]

Medical uses

Tinidazole may be a therapeutic alternative in the setting of metronidazole intolerance. Tinidazole is used to treat Helicobacter pylori, Amoebic dysentery, Giardia and Trichomonas vaginalis.^[4]

Side effects

Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.^{[medical citation needed]}

Half-life

Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.^{[medical citation needed]}

References