Toxiferine
Chemical compound
- 302-30-7
- 5281411
- 4444760
- 9M7D9K3OJI
- ChEMBL231047
- DTXSID30897243
- Interactive image
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Toxiferine (C-toxiferine I) is a curare toxin. It is a bisindole alkaloid derived from Strychnos toxifera and a nicotinic acetylcholine receptor antagonist. This alkaloid is the main toxic component of Calabash curare, and one of the most toxic plant alkaloids known. The lethal dose (LD50) for mice has been determined as 10 - 60 µg/kg by intravenous administration.[1] It is a muscle relaxant that causes paralysis of skeletal muscle, which takes approximately 2 hours to recovery for a moderate dose, and 8 hours of total paralysis with a 20-fold paralytic dose. The paralysis can be antagonized by neostigmine[2]
References
- ^ Entry on C-Toxiferine I. at: Römpp Online. Georg Thieme Verlag, retrieved 8 June 2020.Error in template * unknown parameter name (Template:RömppOnline): "vauthors"
- ^ Saxton JE, Gorman AA, Hesse M, Schmid H, Waser PG, Hopff WH (1971). "Bisindole alkaloids". In Saxton JE (ed.). The Alkaloids: v. 1: A Review of Chemical Literature. Specialist Periodical Reports. Cambridge, Eng: Royal Society of Chemistry. p. 330. ISBN 0-85186-257-8.
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toxins
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- Aflatoxin
- Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin)
- beta-Nitropropionic acid
- Citrinin
- Cytochalasin
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- Fumonisin (Fumonisin B1, Fumonisin B2, Fumonisin B3, Fumonisin B4)
- Gliotoxin
- Ibotenic acid
- Lolitrem B
- Muscimol
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- Patulin
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- Vomitoxin
- Zeranol
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- Anisatin
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- Resiniferatoxin
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- Strychnine
- Swainsonine
- Tagetitoxin
- Tinyatoxin
- Tomatine
- Toxalbumin
- Tutin
toxins
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toxins
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- note: some toxins are produced by lower species and pass through intermediate species
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