Transmembrane Protein 205

Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene.

TMEM205
Identifiers
Aliases	TMEM205, UNQ501, transmembrane protein 205
External IDs	OMIM: 613771 MGI: 3045495 HomoloGene: 43895 GeneCards: TMEM205
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 11,342,776 bp[1] End 11,346,518 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,832,304 bp[2] End 21,838,852 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right lobe of liver right lobe of thyroid gland left lobe of thyroid gland anterior pituitary prefrontal cortex body of pancreas right uterine tube Brodmann area 9 cingulate gyrus Top expressed in left lobe of liver adrenal gland proximal tubule spermatid kidney right ventricle brown adipose tissue seminiferous tubule white adipose tissue facial motor nucleus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 374882 235043 Ensembl ENSG00000105518 ENSMUSG00000040883 UniProt Q6UW68 Q91XE8 RefSeq (mRNA) NM_001145416 NM_033408 NM_198536 NM_001321112 NM_001321113 NM_001321114 NM_001253867 NM_001253868 NM_001253869 NM_001253870 NM_178577 RefSeq (protein) NP_001138888 NP_001308041 NP_001308042 NP_001308043 NP_212133 NP_940938 NP_001240796 NP_001240797 NP_001240798 NP_001240799 NP_848692 Location (UCSC) Chr 19: 11.34 – 11.35 Mb Chr 9: 21.83 – 21.84 Mb PubMed search [3] [4]
Wikidata
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Gene

TMEM205 is located on the minus strand of chromosome 19 from base pair 11,453,452 to 11,456,981. In close proximity to TMEM205, CCDC159 is located slightly upstream and RAB3D slightly down stream of the genomic sequence.

Homology

TMEM205 has no known Paralogs in the Human genome. Using UCSC genome browser BLAT^[5] against the human protein sequence it was found that the closest relative to humans to contain a paralog of the TMEM205 gene in its genome is the Bushbaby. TMEM205 does however have a large range of ortholog sequences.

Protein

The human homologue of TMEM205 is 189 amino acids long and has a molecular weight of 21.2 kDa. It contains 4 hydrophobic helical domains that are predicted to be transmembrane domains.

Expression

TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues.^[17] The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.

Function

TMEM205 is thought to be a multi-pass transmembrane protein. It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin.^[17] It contains four domains predicted to be trans membrane domains by TMHMM analysis.

Interacting proteins

TMEM205 has been shown to be co-located with RAB8 a known GTPase involved in vesicular traffic.^[18]

Clinical significance

TMEM205 has been shown to be involved in Cisplatin resistance. Cisplatin is a chemotherapeutic drug that is commonly used to treat solid malignancies such as carcinomas, sarcomas, and lymphomas. In addition to being involved in Cisplatin resistance there is growing evidence that the protein is also involved in the diseases thyroiditis and prostatitis

Notes