Tromantadine
Antiviral medicine used to treat herpes simplex virus
- D06BB02 (WHO) J05AC03 (WHO)
- US: Not FDA-approved
- OTC (RU)
- N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
- 53783-83-8
N
- 64377
- 57947
Y
- H191JFG8WA
- D07199 Y
- 007760
- DTXSID00202062
- Interactive image
- O=C(NC13CC2CC(CC(C1)C2)C3)COCCN(C)C
InChI
- InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)Y
- Key:UXQDWARBDDDTKG-UHFFFAOYSA-NY
N
Y (what is this?) (verify)Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.[1][2]
Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.
Mechanism
Tromantadine inhibits the early and late events in the virus replication cycle.[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.[citation needed]
References
- ^ Ostheimer KE, Busch T, Görtelmeyer R, Hahn KD (September 1989). "Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis". Arzneimittel-Forschung. 39 (9): 1152–1155. PMID 2686658.
- ^ Diezel W, Michel G, Görtelmeyer R, Ostheimer KE (April 1993). "Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial". Arzneimittel-Forschung. 43 (4): 491–496. PMID 8494582.
- ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrobial Agents and Chemotherapy. 22 (6): 1031–1036. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383.
External links
- Viru-Merz website
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