UBE2L6

Protein-coding gene in the species Homo sapiens
UBE2L6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WZV, 1WZW, 2KJH

Identifiers
AliasesUBE2L6, RIG-B, UBCH8, ubiquitin conjugating enzyme E2 L6
External IDsOMIM: 603890 MGI: 1914500 HomoloGene: 3112 GeneCards: UBE2L6
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for UBE2L6
Genomic location for UBE2L6
Band11q12.1Start57,551,656 bp[1]
End57,568,284 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for UBE2L6
Genomic location for UBE2L6
Band2|2 DStart84,629,172 bp[2]
End84,640,679 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • palpebral conjunctiva

  • ganglionic eminence

  • lymph node

  • spleen

  • appendix

  • gallbladder

  • stromal cell of endometrium

  • blood

  • right lung
Top expressed in
  • blood

  • yolk sac

  • spleen

  • blastocyst

  • duodenum

  • jejunum

  • aortic valve

  • ascending aorta

  • lip

  • morula
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • ubiquitin-like protein transferase activity
  • transferase activity
  • ISG15 transferase activity
  • protein binding
  • ubiquitin-protein transferase activity
  • ubiquitin binding
  • ubiquitin protein ligase binding
  • ubiquitin conjugating enzyme activity
Cellular component
  • cytosol
  • nucleoplasm
  • ubiquitin ligase complex
Biological process
  • ISG15-protein conjugation
  • translesion synthesis
  • negative regulation of type I interferon production
  • modification-dependent protein catabolic process
  • protein ubiquitination
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9246

56791

Ensembl

ENSG00000156587

ENSMUSG00000027078

UniProt

O14933

Q9QZU9

RefSeq (mRNA)

NM_198183
NM_004223

NM_019949

RefSeq (protein)

NP_004214
NP_937826

NP_064333

Location (UCSC)Chr 11: 57.55 – 57.57 MbChr 2: 84.63 – 84.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1S), ubiquitin-conjugating enzymes (E2S) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family.

This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156587 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027078 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kumar S, Kao WH, Howley PM (Jul 1997). "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity". J Biol Chem. 272 (21): 13548–54. doi:10.1074/jbc.272.21.13548. PMID 9153201.
  6. ^ a b "Entrez Gene: UBE2L6 ubiquitin-conjugating enzyme E2L 6".

Further reading

  • Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J. Biol. Chem. 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091.
  • Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J. Biol. Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
  • Huang L, Kinnucan E, Wang G, et al. (1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade". Science. 286 (5443): 1321–6. doi:10.1126/science.286.5443.1321. PMID 10558980.
  • Nyman TA, Matikainen S, Sareneva T, et al. (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi:10.1046/j.1432-1327.2000.01433.x. PMID 10866800.
  • Ardley HC, Rose SA, Tan N, et al. (2000). "Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12". Cytogenet. Cell Genet. 89 (1–2): 137–40. doi:10.1159/000015593. PMID 10894956. S2CID 502452.
  • Zhang Y, Gao J, Chung KK, et al. (2001). "Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13354–9. doi:10.1073/pnas.240347797. PMC 27228. PMID 11078524.
  • Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
  • Wheeler TC, Chin LS, Li Y, et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". J. Biol. Chem. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535.
  • Urano T, Saito T, Tsukui T, et al. (2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature. 417 (6891): 871–5. Bibcode:2002Natur.417..871U. doi:10.1038/nature00826. PMID 12075357. S2CID 4348545.
  • Chin LS, Vavalle JP, Li L (2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation". J. Biol. Chem. 277 (38): 35071–9. doi:10.1074/jbc.M203300200. PMID 12121982.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. S2CID 39773935.
  • Zhao C, Beaudenon SL, Kelley ML, et al. (2004). "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein". Proc. Natl. Acad. Sci. U.S.A. 101 (20): 7578–82. Bibcode:2004PNAS..101.7578Z. doi:10.1073/pnas.0402528101. PMC 419648. PMID 15131269.
  • Tripathi MK, Chaudhuri G (2005). "Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells". Biochem. Biophys. Res. Commun. 328 (1): 43–8. doi:10.1016/j.bbrc.2004.12.142. PMC 3085986. PMID 15670748.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Li J, Wang J, Yang X, et al. (2007). "The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8". Mol. Cell. Biochem. 288 (1–2): 151–7. doi:10.1007/s11010-006-9131-9. PMID 16583136. S2CID 24935755.
  • v
  • t
  • e
  • 1wzv: Crystal Structure of UbcH8
    1wzv: Crystal Structure of UbcH8
  • 1wzw: Crystal Structure of UbcH8
    1wzw: Crystal Structure of UbcH8
  • v
  • t
  • e
Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targeting
Ubiquitin
(ubiquitylation)
Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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