USP40

Protein-coding gene in the species Homo sapiens
USP40
Identifiers
AliasesUSP40, ubiquitin specific peptidase 40
External IDsOMIM: 610570 MGI: 2443184 HomoloGene: 32400 GeneCards: USP40
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for USP40
Genomic location for USP40
Band2q37.1Start233,475,520 bp[1]
End233,566,782 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for USP40
Genomic location for USP40
Band1|1 DStart87,945,119 bp[2]
End88,008,551 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • right uterine tube

  • Achilles tendon

  • sural nerve

  • skin of abdomen

  • left adrenal gland

  • right lobe of liver

  • body of stomach

  • corpus callosum
Top expressed in
  • hand

  • spermatocyte

  • lens

  • fossa

  • condyle

  • Paneth cell

  • jejunum

  • ascending aorta

  • maxillary prominence

  • neural tube
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • thiol-dependent deubiquitinase
  • peptidase activity
  • cysteine-type peptidase activity
  • hydrolase activity
  • cysteine-type endopeptidase activity
Cellular component
  • cytoplasm
  • nucleus
  • cytosol
Biological process
  • protein deubiquitination
  • ubiquitin-dependent protein catabolic process
  • proteolysis
  • regulation of protein stability
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55230

227334

Ensembl

ENSG00000085982

ENSMUSG00000005501

UniProt

Q9NVE5

Q8BWR4

RefSeq (mRNA)

NM_018218
NM_001365479

NM_001033291
NM_001198573

RefSeq (protein)
NP_060688
NP_001352408
NP_001369224
NP_001369225
NP_001369226

NP_001369227
NP_001369228
NP_001369229
NP_001369230
NP_001369231
NP_001369232

NP_001028463
NP_001185502

Location (UCSC)Chr 2: 233.48 – 233.57 MbChr 1: 87.95 – 88.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 40 is an enzyme that in humans is encoded by the USP40 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085982 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005501 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP40 ubiquitin specific peptidase 40".

Further reading

  • Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA". Annu. Rev. Biochem. 71 (1): 817–46. doi:10.1146/annurev.biochem.71.110601.135501. PMC 1823043. PMID 12045112.
  • Chen X, Zhang Y, Douglas L, Zhou P (2002). "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation". J. Biol. Chem. 276 (51): 48175–82. doi:10.1074/jbc.M106808200. PMID 11673459.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Li Y, Schrodi S, Rowland C, et al. (2006). "Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease". Hum. Mutat. 27 (10): 1017–23. doi:10.1002/humu.20382. PMID 16917932. S2CID 43881832.


  • v
  • t
  • e