V-erbA-related gene

NR2F6
Identifiers
Aliases	NR2F6, EAR-2, EAR2, ERBAL2, nuclear receptor subfamily 2 group F member 6
External IDs	OMIM: 132880 MGI: 1352453 HomoloGene: 7706 GeneCards: NR2F6
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,231,883 bp[1] End 17,245,919 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.43 cM Start 71,826,767 bp[2] End 71,834,604 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland jejunal mucosa palpebral conjunctiva right lobe of liver corpus epididymis triceps brachii muscle pylorus epithelium of esophagus placenta duodenum Top expressed in Paneth cell proximal tubule left lobe of liver internal carotid artery external carotid artery cumulus cell somite ascending aorta duodenum renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding nuclear receptor activity DNA-binding transcription factor activity DNA binding protein binding steroid hormone receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process transcription, DNA-templated signal transduction detection of temperature stimulus involved in sensory perception of pain entrainment of circadian clock by photoperiod negative regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter neuron development regulation of transcription, DNA-templated intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2063 13864 Ensembl ENSG00000160113 ENSMUSG00000002393 UniProt P10588 P43136 RefSeq (mRNA) NM_005234 NM_010150 RefSeq (protein) NP_005225 NP_005225.2 NP_034280 Location (UCSC) Chr 19: 17.23 – 17.25 Mb Chr 8: 71.83 – 71.83 Mb PubMed search [3] [4]
Wikidata
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V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.^[5] V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA (P03373), a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.^[6]

Function

Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.^[7][8]

Nr2f6 knockout mice show defects in development of the locus ceruleus.^[9]

It was found that antigen receptor stimulation-induced NF-AT/AP-1 activity is regulated through the nuclear receptor NR2F6 (NR2F6 acts as a direct repressor of NF-AT/AP-1 transactivation) and that by preventing NR2F6 function, transcriptional activation of NF-AT/AP-1 is enhanced in immune cells which leads to an augmented immune response.^[10]

NR2F6 impairs the formation of mature red blood cells in animals that over-express NR2F6 in their bone marrow. Mice that over expression of NR2F6 in their bone marrow cells have a block at the pro-erythroblast stage of blood cell development both in the bone marrow and in the spleen of animals that have excessive expression of NR2F6. So, when inhibition of differentiation of stem cell is desired, inhibition of differentiation is achieved through induction of increased NR2F6 activity. In situations where differentiation of stem cells into a cell of increased maturity is desired, inhibition of NR2F6 activity must be performed.^[11]

Clinical significance

It was found that expression of NR2F6 was consistently upregulated in neoplastic tissues in leukemic, ovarian cancer and endometrial cancer as compared to non-malignant tissues, while the silencing of NR2F6 induces a reduction of cancer cell proliferation, inhibiting clonogenicity and self-renewal of proliferating cancer cells, and induces differentiation.^[12]

Interactions

V-erbA-related gene has been shown to interact with:

• COUP-TFII^[13]
• Thyroid hormone receptor beta^[7]

References

Further reading

External links

• NR2F6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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