VPS33B

Protein-coding gene in the species Homo sapiens
VPS33B
Identifiers
AliasesVPS33B, late endosome and lysosome associated, VPS33B late endosome and lysosome associated
External IDsOMIM: 608552 MGI: 2446237 HomoloGene: 10261 GeneCards: VPS33B
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for VPS33B
Genomic location for VPS33B
Band15q26.1Start90,998,673 bp[1]
End91,022,603 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for VPS33B
Genomic location for VPS33B
Band7|7 D2Start79,919,397 bp[2]
End79,941,502 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • Brodmann area 23

  • middle temporal gyrus

  • amniotic fluid

  • endothelial cell

  • cerebellar hemisphere

  • retinal pigment epithelium

  • prefrontal cortex

  • palpebral conjunctiva

  • anterior pituitary
Top expressed in
  • secondary oocyte

  • supraoptic nucleus

  • saccule

  • aortic valve

  • spermatocyte

  • otic placode

  • ascending aorta

  • morula

  • submandibular gland

  • cerebellar cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • HOPS complex
  • platelet alpha granule
  • recycling endosome
  • AP-3 adaptor complex
  • endosome
  • late endosome
  • early endosome membrane
  • membrane
  • late endosome membrane
  • clathrin complex
  • lysosomal membrane
  • early endosome
  • perinuclear region of cytoplasm
  • lysosome
  • cytoplasmic vesicle
  • clathrin-coated vesicle
Biological process
  • megakaryocyte development
  • endosome to lysosome transport
  • platelet alpha granule organization
  • membrane fusion
  • melanosome localization
  • endosome organization
  • vesicle docking involved in exocytosis
  • autophagosome maturation
  • lysosome localization
  • transport
  • protein transport
  • vesicle-mediated transport
  • regulation of platelet aggregation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26276

233405

Ensembl

ENSG00000184056

ENSMUSG00000030534

UniProt

Q9H267

P59016

RefSeq (mRNA)

NM_001289148
NM_001289149
NM_018668

NM_178070

RefSeq (protein)

NP_001276077
NP_001276078
NP_061138

NP_835171

Location (UCSC)Chr 15: 91 – 91.02 MbChr 7: 79.92 – 79.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 33B is a protein that in humans is encoded by the VPS33B gene.[5][6]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184056 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030534 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pevsner J, Hsu SC, Hyde PS, Scheller RH (Dec 1996). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene. 183 (1–2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080.
  6. ^ a b "Entrez Gene: VPS33B vacuolar protein sorting 33 homolog B (yeast)".

Further reading

  • Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M (2000). "Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b". Cytogenetics and Cell Genetics. 89 (1–2): 92–5. doi:10.1159/000015571. PMID 10894945. S2CID 38825448.
  • Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H (Feb 2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33". Gene. 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
  • Gissen P, Johnson CA, Morgan NV, Stapelbroek JM, Forshew T, Cooper WN, McKiernan PJ, Klomp LW, Morris AA, Wraith JE, McClean P, Lynch SA, Thompson RJ, Lo B, Quarrell OW, Di Rocco M, Trembath RC, Mandel H, Wali S, Karet FE, Knisely AS, Houwen RH, Kelly DA, Maher ER (Apr 2004). "Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome". Nature Genetics. 36 (4): 400–4. doi:10.1038/ng1325. PMID 15052268.
  • Gissen P, Johnson CA, Gentle D, Hurst LD, Doherty AJ, O'Kane CJ, Kelly DA, Maher ER (May 2005). "Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights". Human Molecular Genetics. 14 (10): 1261–70. doi:10.1093/hmg/ddi137. PMID 15790593.
  • Lo B, Li L, Gissen P, Christensen H, McKiernan PJ, Ye C, Abdelhaleem M, Hayes JA, Williams MD, Chitayat D, Kahr WH (Dec 2005). "Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis". Blood. 106 (13): 4159–66. doi:10.1182/blood-2005-04-1356. PMID 16123220.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • v
  • t
  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders


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