WAY-213,613

Chemical compound

WAY-213,613
Identifiers

IUPAC name (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid
CAS Number	868359-05-1^Y
PubChem CID	11531745
IUPHAR/BPS	4531
ChemSpider	9706528^N
UNII	8QTE6AZR4F
ChEMBL	ChEMBL1628669^N
CompTox Dashboard (EPA)	DTXSID60468142
ECHA InfoCard	100.212.988
Chemical and physical data
Formula	C₁₆H₁₃BrF₂N₂O₄
Molar mass	415.191 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1NC(=O)C[C@@H](C(=O)O)N)OC2=CC(=C(C=C2Br)F)F
InChI InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1^N Key:BNYDDAAZMBUFRG-ZDUSSCGKSA-N^N
^NY (what is this?) (verify)

WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT₂, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors.^[1] It is used in scientific research into the function of the glutamate transporters.^[2]

References

^ Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, et al. (October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology. 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID 16014807. S2CID 24207924.
^ Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P (July 2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience. 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID 19364521. S2CID 23641405.

Glutamate metabolism and transport modulators

Transporter

EAATsTooltip Excitatory amino acid transporters	Amphetamine Aspartic acid (aspartate) cis-ACBD DHKA Glutamic acid (glutamate) HIP-A HIP-B Kainic acid L-(-)-threo-3-Hydroxyaspartic acid L-αAA L-CCG-III ((2S,3S,4R)-CCG) L-Serine-O-sulphate (SOS) L-trans-2,4-PDC MPDC Maslinic acid SYM-2081 TBOA TFB-TBOA Theanine threo-3-Methylglutamic acid UCPH-101 WAY-213,613
vGluTsTooltip Vesicular glutamate transporters	4-Methylene-L-glutamate 6-(4'-Phenylstyryl)-QDC 6-Biphenyl-4-yl-QDC 7-CKA Acid red 114 Amido black 10B (naphthol blue black) Bafilomycin A1 Benzopurpurin 4B Bumetamide Chicago sky blue 6B Aspartic acid (aspartate) DIDS Direct blue 71 Erythro-4-methyl-L-glutamic acid Evans blue Furosemide Glutamic acid (glutamate) Kynurenic acid Nigericin NPPB (N144) Ponceau SS Reactive blue 2 Rose bengal SITS trans-ACDP Trypan blue Valinomycin Xanthurenic acid

EAATsTooltip Excitatory amino acid transporters

Amphetamine
Aspartic acid (aspartate)
cis-ACBD
DHKA
Glutamic acid (glutamate)
HIP-A
HIP-B
Kainic acid
L-(-)-threo-3-Hydroxyaspartic acid
L-αAA
L-CCG-III ((2S,3S,4R)-CCG)
L-Serine-O-sulphate (SOS)
L-trans-2,4-PDC
MPDC
Maslinic acid
SYM-2081
TBOA
TFB-TBOA
Theanine
threo-3-Methylglutamic acid
UCPH-101
WAY-213,613

vGluTsTooltip Vesicular glutamate transporters

4-Methylene-L-glutamate
6-(4'-Phenylstyryl)-QDC
6-Biphenyl-4-yl-QDC
7-CKA
Acid red 114
Amido black 10B (naphthol blue black)
Bafilomycin A1
Benzopurpurin 4B
Bumetamide
Chicago sky blue 6B
Aspartic acid (aspartate)
DIDS
Direct blue 71
Erythro-4-methyl-L-glutamic acid
Evans blue
Furosemide
Glutamic acid (glutamate)
Kynurenic acid
Nigericin
NPPB (N144)
Ponceau SS
Reactive blue 2
Rose bengal
SITS
trans-ACDP
Trypan blue
Valinomycin
Xanthurenic acid

Enzyme

GAHTooltip Glutamine aminohydrolase (glutaminase)	BPTES CB-839 DON
ASTTooltip Aspartate aminotransferase	2-Amino-3-butenoic acid AAOA AMB β-DL-Methylene-aspartate Hydrazinosuccinate
ALTTooltip Alanine aminotransferase	β-Chloro-L-alanine L-Cycloserine Propargylglycine
GDHTooltip Glutamate dehydrogenase	AAOA Bithionol Chloroquine EGCG GTP GW5074 Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate
GSTooltip Glutamine synthetase	2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin (glufosinate)
GADTooltip Glutamate decarboxylase	3-Mercaptopropionic acid AAOA L-Allylglycine Semicarbazide

See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators