WIPI1

Protein-coding gene in the species Homo sapiens
WIPI1
Identifiers
AliasesWIPI1, ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1
External IDsOMIM: 609224 MGI: 1261864 HomoloGene: 117983 GeneCards: WIPI1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for WIPI1
Genomic location for WIPI1
Band17q24.2Start68,420,948 bp[1]
End68,457,513 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for WIPI1
Genomic location for WIPI1
Band11 E1|11 72.18 cMStart109,464,157 bp[2]
End109,502,793 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • sperm

  • gastrocnemius muscle

  • minor salivary glands

  • biceps brachii

  • left ventricle

  • skeletal muscle tissue

  • sural nerve

  • placenta

  • rectum
Top expressed in
  • seminal vesicula

  • interventricular septum

  • saccule

  • retinal pigment epithelium

  • right ventricle

  • submandibular gland

  • calvaria

  • skeletal muscle tissue

  • ankle

  • lacrimal gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphatidylinositol-3-phosphate binding
  • phosphatidylinositol-3,5-bisphosphate binding
  • androgen receptor binding
  • signaling receptor binding
  • estrogen receptor binding
  • protein binding
  • lipid binding
Cellular component
  • cytoplasm
  • phagophore assembly site membrane
  • endosome
  • Golgi apparatus
  • membrane
  • Golgi membrane
  • trans-Golgi network
  • autophagosome membrane
  • endosome membrane
  • cytoskeleton
  • cytoplasmic vesicle
  • clathrin-coated vesicle
  • phagophore assembly site
  • cytosol
  • extrinsic component of membrane
Biological process
  • vesicle targeting, trans-Golgi to endosome
  • autophagy
  • IRE1-mediated unfolded protein response
  • macroautophagy
  • autophagy of mitochondrion
  • protein lipidation
  • protein localization to phagophore assembly site
  • autophagy of nucleus
  • autophagosome assembly
  • cellular response to starvation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55062

52639

Ensembl

ENSG00000070540

ENSMUSG00000041895

UniProt

Q5MNZ9

Q8R3E3

RefSeq (mRNA)

NM_017983
NM_001320772

NM_145940

RefSeq (protein)

NP_001307701
NP_060453

NP_666052

Location (UCSC)Chr 17: 68.42 – 68.46 MbChr 11: 109.46 – 109.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.[5][6][7]

Structure and function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.[5][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070540 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041895 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WD repeat domain".
  6. ^ Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
  7. ^ a b Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.

Further reading

  • Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM (November 2009). "Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis". PLOS Genet. 5 (11): e1000730. doi:10.1371/journal.pgen.1000730. PMC 2777390. PMID 19936222.
  • Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010). "Network organization of the human autophagy system". Nature. 466 (7302): 68–76. Bibcode:2010Natur.466...68B. doi:10.1038/nature09204. PMC 2901998. PMID 20562859.
  • Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (July 2007). "Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy". FEBS Lett. 581 (18): 3396–404. doi:10.1016/j.febslet.2007.06.040. PMID 17618624. S2CID 23430881.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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