Wellcome Centre for Human Genetics
Research Institute at the University of Oxford
51°45′08″N 1°12′55″W / 51.752248°N 1.215255°W / 51.752248; -1.215255
The Wellcome Centre for Human Genetics is a human genetics research centre of the Nuffield Department of Medicine in the Medical Sciences Division, University of Oxford, funded by the Wellcome Trust among others.[1]
Facilities & resources
The centre is located at the Henry Wellcome Building of Genomic Medicine, which cost £20 million and was officially opened in June 2000 with Anthony Monaco as the director.[2][3]
Within the WHG a number of 'cores' provide services to the researchers:
Oxford Genomics Centre
The Oxford Genomics Centre provides high throughput sequencing services, using Illumina HiSeq4000 2500 and NextSeq500 and MiSeq.[4] They also offer Oxford Nanopore MinION and PromethION sequencing.[4] There are also Array platforms for genotyping, gene expression, and methylation including Illuminia Infinium, Affymetrix and Fluidigm.[5]
Research Computing Core
The Research Computing Core provides access to computer resources including 4120 cores and 4.2 PB of storage.[6]
Transgenics
The Transgenics Core provides access to genetically modified mice and cell lines.[7]
Cellular Imaging
Cellular Imaging Core provides microscopy facilities including fluorescence microscopy (including Fluorescence Correlation Spectroscopy (FCS), Fluorescence Lifetime Correlation Spectroscopy (FLCS), Fluorescence Lifetime Imaging Microscopy (FLIM), Total Internal Reflection Fluorescence Microscopy (TIRF), Photoactivated Localisation Microscopy (PALM), Spectral Imaging (SI) and Single Particle Tracking (SPT).[8]
Research
Statistical and population genetics
The WHG has been involved in many international statistical genetics advances including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the 1000 Genomes Project and the International HapMap Project.[9]
References
- ^ "Welcome to the WHG". well.ox.ac.uk. Retrieved 21 November 2018.
- ^ Farrar, Steve (2000). "Vanguard digs deep into data at Oxford". Times Higher Education. Retrieved 19 December 2011. [dead link]
- ^ Ramagopalan, S. V. (2008). "Life on top—working@ the Wellcome Trust Centre for Human Genetics: Scotland Yard for DNA detectives". New Biotechnology. 25 (1): 39–45. doi:10.1016/j.nbt.2008.04.007. PMID 18504015.
- ^ a b "Sequencing - Oxford Genomics Centre". Oxford Genomics Centre. Retrieved 1 December 2017.
- ^ "Arrays - Oxford Genomics Centre". Oxford Genomics Centre. Retrieved 1 December 2017.
- ^ DDN Storage (2 November 2016), Making high-performance compute appropriate to population-scale biomedical data, retrieved 1 December 2017
- ^ "Transgenics Core". Retrieved 1 December 2017.
- ^ "Cellular Imaging - Wellcome Trust Centre for Human Genetics". www.well.ox.ac.uk. Retrieved 1 December 2017.
- ^ "Research areas - Wellcome Trust Centre for Human Genetics". www.well.ox.ac.uk. Retrieved 1 December 2017.
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Wellcome Trust
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- 1000 Genomes Project
- Big Picture
- Cambridge Biomedical Campus
- Cancer Genome Project
- ChEMBL
- Coalition for Epidemic Preparedness Innovations
- COSMIC cancer database
- DECIPHER
- Diamond Light Source
- eLife
- Ensembl
- Farmcare
- Genome Reference Consortium
- Human Genome Project
- Malawi Liverpool Wellcome Trust
- MEROPS
- Pfam
- Rfam
- UK Biobank
- Wellcome Collection
- Wellcome Genome Campus
- Wellcome Library
- WormBase
- Eliza Manningham-Buller
- Michael Ferguson
- Tobias Bonhoeffer
- Alan Brown
- William Burns
- Bryan Grenfell
- Naguib Kheraj
- Fiona Powrie
- Jeremy Farrar
- Chris Bird
- Stephen Caddick
- Simon Chaplin
- Alyson Fox
- Peter Pereira Gray
- Mark Henderson
- Chonnettia Jones
- Tim Livett
- Nick Moakes
- Kathy Poole
- Jim Smith
- James Thomas
- Ed Whiting
- Peter Williams (1965–1991)
- Bridget Ogilvie (1991–1998)
- Michael Dexter (1998–2008)
- Mark Walport (2003–2013)
- Damon Buffini
- William Castell
- Dominic Cadbury
- Harold Cook
- Kay Davies
- Oliver Franks
- Roger Gibbs
- Henry Dale
- Richard Hynes
- Anne Johnson
- Roy Porter
- Peter Rigby
- David Steel
- David Stuart
- John Sulston
- Henry Wellcome
- Capital Awards
- Collaborative Awards in Science
- Investigator Awards in Science
- Institutional Strategic Support Fund
- Science Strategic Award
- Sir Henry Dale Fellowship
- Sir Henry Wellcome Postdoctoral Fellowship
- Wellcome Book Prize
- Wellcome Image Awards
- Wellcome Trust Centre
- Wellcome Trust Principal Research Fellow
- Wellcome Trust Senior Research Fellow
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