ZBTB20

Human protein-coding gene
ZBTB20
Identifiers
AliasesZBTB20, DPZF, HOF, ODA-8S, ZNF288, PRIMS, zinc finger and BTB domain containing 20
External IDsOMIM: 606025 MGI: 1929213 HomoloGene: 9226 GeneCards: ZBTB20
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ZBTB20
Genomic location for ZBTB20
Band3q13.31Start114,314,500 bp[1]
End115,147,288 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for ZBTB20
Genomic location for ZBTB20
Band16 B4|16 28.44 cMStart42,875,881 bp[2]
End43,642,602 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • caput epididymis

  • renal medulla

  • corpus callosum

  • Achilles tendon

  • external globus pallidus

  • trigeminal ganglion

  • urethra

  • synovial joint

  • nipple
Top expressed in
  • utricle

  • median eminence

  • arcuate nucleus

  • ciliary body

  • aortic valve

  • ascending aorta

  • retinal pigment epithelium

  • stria vascularis

  • conjunctival fornix

  • mammillary body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleic acid binding
  • DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • metal ion binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • nuclear body
  • cytoplasm
Biological process
  • positive regulation of tumor necrosis factor production
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of gene expression
  • transcription, DNA-templated
  • positive regulation of interleukin-6 production
  • positive regulation of interferon-beta production
  • positive regulation of glycolytic process
  • positive regulation of lipid biosynthetic process
  • lipid homeostasis
  • cellular response to glucose stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26137

56490

Ensembl

ENSG00000181722

ENSMUSG00000022708

UniProt

Q9HC78

Q8K0L9

RefSeq (mRNA)
NM_001164342
NM_001164343
NM_001164344
NM_001164345
NM_001164346

NM_001164347
NM_015642
NM_001348800
NM_001348802
NM_001348803
NM_001348804
NM_001348805
NM_001348801
NM_001393393
NM_001393394
NM_001393395
NM_001393396

NM_001285805
NM_019778
NM_181058

RefSeq (protein)
NP_001157814
NP_001157815
NP_001157816
NP_001157817
NP_001157818

NP_001157819
NP_056457
NP_001335729
NP_001335731
NP_001335732
NP_001335733
NP_001335734
NP_001335730

NP_001272734
NP_062752
NP_851401
NP_001380326
NP_001380327

NP_001380328

Location (UCSC)Chr 3: 114.31 – 115.15 MbChr 16: 42.88 – 43.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger and BTB domain-containing protein 20 is a protein that in humans is encoded by the ZBTB20 gene.[5][6][7]

There is evidence that ZBTB20 may cause primrose disease.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181722 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022708 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Harboe TL, Tumer Z, Hansen C, Jensen NA, Tommerup N (Sep 2000). "Assignment of the human zinc finger gene, ZNF288, to chromosome 3 band q13.2 by radiation hybrid mapping and fluorescence in situ hybridisation". Cytogenet Cell Genet. 89 (3–4): 156–7. doi:10.1159/000015600. PMID 10965110. S2CID 36861164.
  6. ^ Zhang W, Mi J, Li N, Sui L, Wan T, Zhang J, Chen T, Cao X (May 2001). "Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6". Biochem Biophys Res Commun. 282 (4): 1067–73. doi:10.1006/bbrc.2001.4689. PMID 11352661.
  7. ^ "Entrez Gene: ZBTB20 zinc finger and BTB domain containing 20".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Cordeddu, Viviana; Redeker, Bert; Stellacci, Emilia; Jongejan, Aldo; Fragale, Alessandra; Bradley, Ted E. J.; Anselmi, Massimiliano; Ciolfi, Andrea; Cecchetti, Serena; Muto, Valentina; Bernardini, Laura; Azage, Meron; Carvalho, Daniel R.; Espay, Alberto J.; Male, Alison; Molin, Anna-Maja; Posmyk, Renata; Battisti, Carla; Casertano, Alberto; Melis, Daniela; van Kampen, Antoine; Baas, Frank; Mannens, Marcel M.; Bocchinfuso, Gianfranco; Stella, Lorenzo; Tartaglia, Marco; Hennekam, Raoul C. (August 2014). "Mutations in ZBTB20 cause Primrose syndrome". Nature Genetics. 46 (8): 815–817. doi:10.1038/ng.3035. PMID 25017102. S2CID 23567698.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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