ZMYND8

Protein-coding gene in the species Homo sapiens
ZMYND8
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

4COS

Identifiers
AliasesZMYND8, PRKCBP1, PRO2893, RACK7, zinc finger MYND-type containing 8
External IDsOMIM: 615713 MGI: 1918025 HomoloGene: 32679 GeneCards: ZMYND8
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ZMYND8
Genomic location for ZMYND8
Band20q13.12Start47,209,214 bp[1]
End47,356,889 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ZMYND8
Genomic location for ZMYND8
Band2|2 H3Start165,626,072 bp[2]
End165,740,936 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • oocyte

  • caput epididymis

  • pons

  • superior surface of tongue

  • superior vestibular nucleus

  • trigeminal ganglion

  • trabecular bone

  • pylorus

  • middle temporal gyrus
Top expressed in
  • medullary collecting duct

  • primitive streak

  • retinal pigment epithelium

  • urothelium

  • renal corpuscle

  • mucosa of urinary bladder

  • iris

  • facial motor nucleus

  • left lung lobe

  • yolk sac
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • transcription corepressor activity
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • chromatin binding
  • transcription coregulator activity
  • protein binding
  • metal ion binding
  • methylated histone binding
  • lysine-acetylated histone binding
  • protein N-terminus binding
  • zinc ion binding
  • protein domain specific binding
Cellular component
  • cytoplasm
  • dendritic shaft
  • dendritic spine
  • nucleus
Biological process
  • regulation of postsynaptic density protein 95 clustering
  • positive regulation of filopodium assembly
  • positive regulation of dendritic spine development
  • positive regulation of dendritic spine maintenance
  • modulation of excitatory postsynaptic potential
  • transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of cell migration
  • negative regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23613

228880

Ensembl

ENSG00000101040

ENSMUSG00000039671

UniProt

Q9ULU4

n/a

RefSeq (mRNA)
NM_001281769
NM_001281771
NM_001281772
NM_001281773
NM_001281774

NM_001281775
NM_001281776
NM_001281777
NM_001281778
NM_001281779
NM_001281780
NM_001281781
NM_001281782
NM_001281783
NM_001281784
NM_012408
NM_183047
NM_183048
NM_001363714
NM_001363741

NM_001252584
NM_001252585
NM_001252587
NM_001281926
NM_001291158

NM_027230
NM_172270
NM_001363018
NM_001363019
NM_001363020
NM_001363021

RefSeq (protein)
NP_001268698
NP_001268700
NP_001268701
NP_001268702
NP_001268703

NP_001268704
NP_001268705
NP_001268706
NP_001268707
NP_001268708
NP_001268709
NP_001268710
NP_001268711
NP_001268712
NP_001268713
NP_036540
NP_898868
NP_898869
NP_001350643
NP_001350670

n/a

Location (UCSC)Chr 20: 47.21 – 47.36 MbChr 2: 165.63 – 165.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein kinase C-binding protein 1 is an enzyme that in humans is encoded by the ZMYND8 gene.[5]

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101040 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039671 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ZMYND8 zinc finger, MYND-type containing 8".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Mahony D, Kalionis B, Antalis TM (1999). "Plasminogen activator inhibitor type-2 (PAI-2) gene transcription requires a novel NF-kappaB-like transcriptional regulatory motif". Eur. J. Biochem. 263 (3): 765–72. doi:10.1046/j.1432-1327.1999.00552.x. PMID 10469140.
  • Hirosawa M; Nagase T; Ishikawa K; et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  • Fossey SC; Kuroda S; Price JA; et al. (2000). "Identification and characterization of PRKCBP1, a candidate RACK-like protein". Mamm. Genome. 11 (10): 919–25. doi:10.1007/s003350010174. PMID 11003709. S2CID 646555.
  • Eichmuller S; Usener D; Dummer R; et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
  • Deloukas P; Matthews LH; Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Galey D; Becker K; Haughey N; et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.
  • Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Westendorf JJ, Koka S (2004). "Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics". J. Cell. Biochem. 92 (1): 29–41. doi:10.1002/jcb.20031. PMID 15095401. S2CID 40202935.
  • Colland F; Jacq X; Trouplin V; et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Miles RR, Crockett DK, Lim MS, Elenitoba-Johnson KS (2006). "Analysis of BCL6-interacting proteins by tandem mass spectrometry". Mol. Cell. Proteomics. 4 (12): 1898–909. doi:10.1074/mcp.M500112-MCP200. PMID 16147992.
  • Lim J; Hao T; Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.