ZNF146

Protein-coding gene in the species Homo sapiens
ZNF146
Identifiers
AliasesZNF146, OZF, zinc finger protein 146
External IDsOMIM: 601505 MGI: 1347092 HomoloGene: 117615 GeneCards: ZNF146
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ZNF146
Genomic location for ZNF146
Band19q13.12Start36,214,602 bp[1]
End36,238,771 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ZNF146
Genomic location for ZNF146
Band7|7 B1Start29,860,694 bp[2]
End29,869,175 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parietal pleura

  • amniotic fluid

  • lactiferous duct

  • germinal epithelium

  • visceral pleura

  • tibia

  • inferior ganglion of vagus nerve

  • subthalamic nucleus

  • pericardium

  • endometrium
Top expressed in
  • yolk sac

  • ganglionic eminence

  • superior frontal gyrus

  • otic placode

  • lip

  • lens

  • urethra

  • dermis

  • thymus

  • male urethra
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • zinc ion binding
  • heparin binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleolus
  • nucleus
  • cytosol
Biological process
  • regulation of transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7705

26465

Ensembl

ENSG00000167635

ENSMUSG00000037029

UniProt

Q15072

Q8BQN6

RefSeq (mRNA)

NM_001099638
NM_001099639
NM_007145

NM_011980
NM_001357557

RefSeq (protein)

NP_001093108
NP_001093109
NP_009076

NP_036110
NP_001344486

Location (UCSC)Chr 19: 36.21 – 36.24 MbChr 7: 29.86 – 29.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein OZF is a protein that in humans is encoded by the ZNF146 gene.[5][6][7]


See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167635 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037029 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Blottiere L, Apiou F, Ferbus D, Guenzi C, Dutrillaux B, Prosperi MT, Goubin G (Oct 1999). "Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene". Cytogenet Cell Genet. 85 (3–4): 297–300. doi:10.1159/000015316. PMID 10449921. S2CID 39015999.
  6. ^ Hayes H, Le Chalony C, Goubin G, Mercier D, Payen E, Bignon C, Kohno K (Jul 1996). "Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on homoeologous cattle, sheep and goat chromosomes by fluorescent in situ hybridization and comparison with the human gene map". Cytogenet Cell Genet. 72 (4): 342–6. doi:10.1159/000134218. PMID 8641144.
  7. ^ "Entrez Gene: ZNF146 zinc finger protein 146".

Further reading

  • Le Chalony C, Prospéri MT, Haluza R, et al. (1994). "The OZF gene encodes a protein consisting essentially of zinc finger motifs". J. Mol. Biol. 236 (2): 399–404. doi:10.1006/jmbi.1994.1151. PMID 8107129.
  • Ferbus D, Le Chalony C, Prospéri MT, et al. (1996). "Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs". Eur. J. Biochem. 236 (3): 991–5. doi:10.1111/j.1432-1033.1996.00991.x. PMID 8665923.
  • Ferbus D, Fléchon A, Muleris M, et al. (1999). "Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas". Int. J. Cancer. 80 (3): 369–72. doi:10.1002/(SICI)1097-0215(19990129)80:3<369::AID-IJC6>3.0.CO;2-Y. PMID 9935176.
  • Pibouin L, Villaudy J, Prospéri MT, Goubin G (2001). "Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains". Cytogenet. Cell Genet. 92 (1–2): 80–4. doi:10.1159/000056873. PMID 11306801. S2CID 23868551.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ferbus D, Bovin C, Validire P, Goubin G (2003). "The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer". J. Pathol. 200 (2): 177–82. doi:10.1002/path.1337. PMID 12754738. S2CID 477806.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Antoine K, Ferbus D, Kolahgar G, et al. (2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". J. Cell. Biochem. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID 15838871. S2CID 10264323.
  • Antoine K, Prosperi MT, Ferbus D, et al. (2005). "A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo". Mol. Cell. Biochem. 271 (1–2): 215–23. doi:10.1007/s11010-005-6417-2. PMID 15881673. S2CID 10800223.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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