ZNF16

Protein-coding gene in the species Homo sapiens
ZNF16
Identifiers
AliasesZNF16, HZF1, KOX9, zinc finger protein 16
External IDsOMIM: 601262 HomoloGene: 56008 GeneCards: ZNF16
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ZNF16
Genomic location for ZNF16
Band8q24.3Start144,930,358 bp[1]
End144,950,888 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • ganglionic eminence

  • gastrocnemius muscle

  • secondary oocyte

  • skin of abdomen

  • stromal cell of endometrium

  • body of pancreas

  • metanephric glomerulus

  • gallbladder

  • endothelial cell
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleolus
Biological process
  • positive regulation of cell cycle phase transition
  • positive regulation of kinase activity
  • cell cycle
  • negative regulation of apoptotic process
  • regulation of transcription, DNA-templated
  • positive regulation of megakaryocyte differentiation
  • positive regulation of cell division
  • positive regulation of erythrocyte differentiation
  • transcription, DNA-templated
  • positive regulation of cell population proliferation
  • cellular response to sodium dodecyl sulfate
  • cell division
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7564

n/a

Ensembl

ENSG00000170631

n/a

UniProt

P17020

n/a

RefSeq (mRNA)

NM_001029976
NM_006958

n/a

RefSeq (protein)

NP_001025147
NP_008889

n/a

Location (UCSC)Chr 8: 144.93 – 144.95 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger protein 16 is a protein that in humans is encoded by the ZNF16 gene.[3]

The protein encoded by this gene contains a C2H2 type of zinc finger, and thus may function as a transcription factor. This gene is located in a region close to ZNF7/KOX4, a gene also encoding a zinc finger protein, on chromosome 8. Two alternatively spliced variants, encoding the same protein, have been identified.[3]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170631 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: ZNF16 zinc finger protein 16".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Dreier B, Segal DJ, Barbas CF (2000). "Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains". J. Mol. Biol. 303 (4): 489–502. doi:10.1006/jmbi.2000.4133. PMID 11054286.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Rousseau-Merck MF, Duro D, Berger R, Thiesen HJ (1995). "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22". Ann. Genet. 38 (2): 81–4. PMID 7486829.
  • Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.


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