ZNF22

Protein-coding gene in the species Homo sapiens
ZNF22
Identifiers
AliasesZNF22, HKR-T1, KOX15, ZNF422, Zfp422, zinc finger protein 22
External IDsOMIM: 194529 MGI: 1914505 HomoloGene: 5067 GeneCards: ZNF22
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ZNF22
Genomic location for ZNF22
Band10q11.21Start45,000,923 bp[1]
End45,005,326 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for ZNF22
Genomic location for ZNF22
Band6|6 E3Start116,600,977 bp[2]
End116,605,960 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • secondary oocyte

  • islet of Langerhans

  • body of pancreas

  • endometrium

  • lymph node

  • Achilles tendon

  • trabecular bone

  • tibia

  • retinal pigment epithelium
Top expressed in
  • ganglionic eminence

  • neural tube

  • mesencephalon

  • thymus

  • stomach

  • lens

  • limb

  • heart

  • proximal tubule

  • rhombencephalon
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
  • DNA binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • odontogenesis
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7570

67255

Ensembl

ENSG00000165512

ENSMUSG00000059878

UniProt

P17026

Q9ERU3

RefSeq (mRNA)

NM_006963

NM_026057
NM_001302439
NM_001302440

RefSeq (protein)

NP_008894
NP_008894.2

NP_001289368
NP_001289369
NP_080333

Location (UCSC)Chr 10: 45 – 45.01 MbChr 6: 116.6 – 116.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 22 is a protein that in humans is encoded by the ZNF22 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165512 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059878 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZNF22 zinc finger protein 22 (KOX 15)".

Further reading

  • Wu BY, Hanley EW, Turka LA, Nabel GJ (1992). "Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines". Blood. 80 (10): 2571–6. doi:10.1182/blood.V80.10.2571.2571. PMID 1421376.
  • Lichter P, Bray P, Ried T, et al. (1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.
  • Rousseau-Merck MF, Tunnacliffe A, Berger R, et al. (1992). "A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10". Genomics. 13 (3): 845–8. doi:10.1016/0888-7543(92)90166-P. PMID 1639412.
  • Bray P, Lichter P, Thiesen HJ, et al. (1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9563–7. Bibcode:1991PNAS...88.9563B. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
  • Huebner K, Druck T, Croce CM, Thiesen HJ (1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". Am. J. Hum. Genet. 48 (4): 726–40. PMC 1682948. PMID 2014798.
  • Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gao Y, Kobayashi H, Ganss B (2004). "The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency)". J. Dent. Res. 82 (12): 1002–7. doi:10.1177/154405910308201213. PMID 14630903. S2CID 22367131.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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