ZNF281

Protein-coding gene in the species Homo sapiens
ZNF281
Identifiers
AliasesZNF281, ZBP-99, ZNP-99, zinc finger protein 281, ZBP99, GZP1
External IDsMGI: 3029290 HomoloGene: 8270 GeneCards: ZNF281
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ZNF281
Genomic location for ZNF281
Band1q32.1Start200,404,940 bp[1]
End200,410,056 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ZNF281
Genomic location for ZNF281
Band1|1 E4Start136,552,639 bp[2]
End136,557,791 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • endothelial cell

  • cerebellar vermis

  • Brodmann area 23

  • spongy bone

  • inferior ganglion of vagus nerve

  • visceral pleura

  • germinal epithelium

  • bone marrow

  • stromal cell of endometrium
Top expressed in
  • olfactory tubercle

  • ascending aorta

  • maxillary prominence

  • superior cervical ganglion

  • hand

  • aortic valve

  • medial geniculate nucleus

  • substantia nigra

  • globus pallidus

  • subiculum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • sequence-specific DNA binding
  • DNA binding
  • transcription corepressor activity
  • DNA-binding transcription factor activity
  • metal ion binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • protein binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleoplasm
  • nucleus
Biological process
  • cell differentiation
  • regulation of transcription, DNA-templated
  • embryonic body morphogenesis
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of gene expression
  • transcription, DNA-templated
  • stem cell differentiation
  • positive regulation of transcription, DNA-templated
  • negative regulation of transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23528

226442

Ensembl

ENSG00000162702

ENSMUSG00000041483

UniProt

Q9Y2X9

Q99LI5

RefSeq (mRNA)

NM_012482
NM_001281293
NM_001281294

NM_001160251
NM_177643

RefSeq (protein)

NP_001268222
NP_001268223
NP_036614

NP_001153723
NP_808311

Location (UCSC)Chr 1: 200.4 – 200.41 MbChr 1: 136.55 – 136.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162702 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041483 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Law DJ, Du M, Law GL, Merchant JL (Sep 1999). "ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression". Biochem Biophys Res Commun. 262 (1): 113–120. doi:10.1006/bbrc.1999.1180. PMID 10448078.
  6. ^ "Entrez Gene: ZNF281 zinc finger protein 281".

Further reading

  • Lisowsky T, Polosa PL, Sagliano A, et al. (1999). "Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence". FEBS Lett. 453 (3): 369–374. doi:10.1016/S0014-5793(99)00754-1. PMID 10405178. S2CID 33226036.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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