Zinc finger protein 165

Protein found in humans
ZNF165
Identifiers
AliasesZNF165, CT53, LD65, ZSCAN7, zinc finger protein 165
External IDsOMIM: 600834 HomoloGene: 122143 GeneCards: ZNF165
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ZNF165
Genomic location for ZNF165
Band6p22.1Start28,080,568 bp[1]
End28,089,563 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • amniotic fluid

  • islet of Langerhans

  • body of pancreas

  • rectum

  • bronchial epithelial cell

  • jejunal mucosa

  • placenta

  • corpus epididymis

  • kidney tubule
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7718

n/a

Ensembl

ENSG00000197279

n/a

UniProt

P49910
Q53Z40

n/a

RefSeq (mRNA)

NM_003447
NM_001376491
NM_001376492
NM_001376493
NM_001376494

n/a

RefSeq (protein)
NP_003438
NP_001363420
NP_001363421
NP_001363422
NP_001363423

NP_003438.1

n/a

Location (UCSC)Chr 6: 28.08 – 28.09 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger protein 165 is a protein that in humans is encoded by the ZNF165 gene.[3][4]

Function

This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis.[4]

Interactions

Zinc finger protein 165 has been shown to interact with Ewing sarcoma breakpoint region 1[5] and DVL2.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197279 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Tirosvoutis KN, Divane A, Jones M, Affara NA (Jan 1996). "Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis". Genomics. 28 (3): 485–90. doi:10.1006/geno.1995.1178. PMID 7490084.
  4. ^ a b "Entrez Gene: ZNF165 zinc finger protein 165".
  5. ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Lee PL, Gelbart T, West C, Adams M, Blackstone R, Beutler E (1997). "Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain". Genomics. 43 (2): 191–201. doi:10.1006/geno.1997.4806. PMID 9244436.
  • Paoloni-Giacobino A, Kern I, Rumpler Y, Djlelati R, Morris MA, Dahoun SP (2001). "Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility". Clin. Genet. 58 (4): 324–8. doi:10.1034/j.1399-0004.2000.580411.x. PMID 11076058. S2CID 19063057.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Stub icon

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e