Nerbio hazkunde-faktore

Identifikadoreak
Taxoia	Homo sapiens
Kokapena
Hasiera	^[1]
Amaiera	^[2]
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Transkripzioak
Gene-adierazpen eredua

Ontologia
Funtzio-molekularrak	Ikusi peptidase inhibitor activity ^(en) enzyme inhibitor activity ^(en) proteina lotura metalloendopeptidase inhibitor activity ^(en) nerve growth factor receptor binding ^(en) growth factor activity ^(en) signaling receptor binding ^(en) nerve growth factor receptor binding ^(en)
Osagai-zelularra	Ikusi endosoma Golgi lumen ^(en) zelulaz kanpoko eremu cytoplasmic vesicle ^(en) zelulaz kanpoko eremu extracellular space ^(en) zitosol synaptic vesicle ^(en) Axoi Dendrita
Prozesu-biologikoak	Ikusi negative regulation of neuron apoptotic process ^(en) regulation of neuron differentiation ^(en) neuron projection morphogenesis ^(en) negative regulation of peptidase activity ^(en) neurotrophin TRK receptor signaling pathway ^(en) cell-cell signaling ^(en) negative regulation of apoptotic process ^(en) regulation of cysteine-type endopeptidase activity involved in apoptotic process ^(en) positive regulation of axonogenesis ^(en) positive regulation of gene expression ^(en) positive regulation of apoptotic process ^(en) nerve growth factor processing ^(en) extrinsic apoptotic signaling pathway via death domain receptors ^(en) phosphatidylinositol-mediated signaling ^(en) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ^(en) microtubule-based movement ^(en) activation of cysteine-type endopeptidase activity involved in apoptotic process ^(en) positive regulation of Ras protein signal transduction ^(en) transmembrane receptor protein tyrosine kinase signaling pathway ^(en) peripheral nervous system development ^(en) Oroimen negative regulation of cell population proliferation ^(en) regulation of signaling receptor activity ^(en) positive regulation of gene expression ^(en) nerve development ^(en) nerve growth factor signaling pathway ^(en) positive regulation of DNA binding ^(en) positive regulation of neuron differentiation ^(en) positive regulation of collateral sprouting ^(en) neuron projection morphogenesis ^(en) modulation of chemical synaptic transmission ^(en)

Nerbio hazkunde-faktore (NGF) faktore neotrofiko eta neuropeptido bat da, neurona zehatz batzuen hazkuntza, mantenu, hedatze eta biziraupenean parte-hartzen duena. Ziurrenik hazkunde-faktore prototipoa da, eta deskribatu zen lehenetako bat izan zen. Rita Levi-Montalcini eta Stanley Cohenek 1956an isolatu eta Medikuntzako Nobel Saria eskuratu zuten. Garai hartatik hainbat prozesu biologiko aurkitu dira NGFk parte-hartzen duena, horietako bi pankreako beta-zelulen biziraupena eta sistema-immunitarioaren erregulazioa izanik.

Azken urteotako ikerketak aurkitu du NGFren kontzentrazioa odol plasman handiagoa dela harreman erromantiko bat izan dutenen artean 12 hilabete baino gehiagoz, izan ez dutenengan baino^[3].

Erreferentziak

↑ GRCh38: Ensembl release 89:. Ensembl.
↑ GRCh38: Ensembl release 89:. Ensembl.
↑ EMANUELE, E; POLITI, P; BIANCHI, M; MINORETTI, P; BERTONA, M; GEROLDI, D. «Raised plasma nerve growth factor levels associated with early-stage romantic love» Psychoneuroendocrinology 31 (3): 288–294. doi:10.1016/j.psyneuen.2005.09.002. (Noiz kontsultatua: 2017-10-23).

Kanpo estekak

Autoritate kontrola	Wikimedia proiektuak Datuak: Q417782 Multimedia: Nerve growth factors / Q417782 Medikuntzako identifikadoreak MeSH: D020932 Kimikako identifikadoreak CAS erregistro zenbakia: 9061-61-4 UNII: V7FWP1D62O Biologiako identifikadoreak MGI: 9061-61-4