Latrofilin 2

ADGRL2

Pengidentifikasi

Alias

ADGRL2, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2

ID eksternal

OMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2

Lokasi gen (Tikus)

Kr.	Kromosom 3 (tikus)^[1]

Pita	3\|3 H3	Awal	148,815,583 bp^[1]
Pita	3\|3 H3	Akhir	148,990,555 bp^[1]

Pola ekspresi RNA

Referensi data ekspresi selengkapnya

Ontologi gen
Fungsi molekuler	• G protein-coupled receptor activity • transmembrane signaling receptor activity • latrotoxin receptor activity • signal transducer activity • carbohydrate binding
Komponen seluler	• komponen integral membran • membran • intracellular anatomical structure • integral component of plasma membrane • neuron projection
Proses biologis	• G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • GO:0072468 signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • brain development
Sumber:Amigo / QuickGO

Ortolog

Spesies

Manusia

Tikus

Entrez


23266


99633

Ensembl


ENSG00000117114


ENSMUSG00000028184

UniProt


O95490


Q8JZZ7

RefSeq (mRNA)

NM_001297704 NM_001297705 NM_001297706 NM_012302 NM_001330645
NM_001350698 NM_001350699 NM_001366002 NM_001366003 NM_001366004 NM_001366005 NM_001366006 NM_001366007 NM_001366008 NM_001366009 NM_001393349 NM_001393350 NM_001393351 NM_001393352 NM_001393353 NM_001393354


NM_001081298

RefSeq (protein)

NP_001284633 NP_001284634 NP_001284635 NP_001317574 NP_036434
NP_001337627 NP_001337628 NP_001352931 NP_001352932 NP_001352933 NP_001352934 NP_001352935 NP_001352936 NP_001352937 NP_001352938

NP_001074767 NP_001392915 NP_001392916 NP_001392917 NP_001392918
NP_001392919 NP_001392920 NP_001392921 NP_001392922 NP_001392923 NP_001392924 NP_001392925 NP_001392926 NP_001392927 NP_001392928 NP_001392929 NP_001392930 NP_001392931 NP_001392932 NP_001392933 NP_001392934 NP_001392935 NP_001392936 NP_001392937 NP_001392938 NP_001392939 NP_001392940 NP_001392947 NP_001392948

Lokasi (UCSC)

n/a

Chr 3: 148.82 – 148.99 Mb

Pencarian PubMed

^[2]

^[3]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Latrofilin 2 adalah protein yang pada manusia disandi oleh gen ADGRL2.^[4]^[5]

Gen ini menyandi anggota subfamili latrofilin reseptor terhubung protein G (GPCR). Latrofilin dapat berfungsi dalam adhesi sel dan transduksi sinyal. Dalam percobaan dengan spesies non-manusia, pembelahan proteolitik endogen dalam GPS yang kaya sistein (situs proteolisis GPCR) menghasilkan dua subunit yaitu fragmen N-terminal dan fragmen C-terminal (subunit dengan kemiripan dengan keluarga sekretin/kalsitonin) dan tidak terikat secara kovalen pada membran sel. Sementara beberapa varian transkrip telah dijelaskan, validitas biologis hanya satu yang telah ditentukan.^[5]

Lihat juga

Reseptor berpasangan protein G adhesi

Bacaan lebih lanjut

Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
White GR, Varley JM, Heighway J (Dec 1998). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer". Oncogene. 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.
Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007 . PMID 17456239.

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta. 1491 (1-3): 75–92. Apr 2000. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
^ ^a ^b "Entrez Gene: LPHN2 latrophilin 2".