PTEN |
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Struktur yang tersedia |
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PDB | Pencarian Ortolog: PDBe RCSB |
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Daftar kode id PDB |
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4O1V, 1D5R, 2KYL, 5BZX, 5BUG, 5BZZ |
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Pengidentifikasi |
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Alias | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, Phosphatase and tensin homolog, PTENbeta |
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ID eksternal | OMIM: 601728 MGI: 109583 HomoloGene: 265 GeneCards: PTEN |
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Lokasi gen (Manusia) |
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| Kr. | Kromosom 10 (manusia)[1] |
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| Pita | 10q23.31 | Awal | 87,862,638 bp[1] |
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Akhir | 87,971,930 bp[1] |
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Lokasi gen (Tikus) |
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| Kr. | Kromosom 19 (tikus)[2] |
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| Pita | 19 C1|19 28.14 cM | Awal | 32,734,897 bp[2] |
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Akhir | 32,803,560 bp[2] |
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Ontologi gen |
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Fungsi molekuler | • phosphoprotein phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity • phosphatidylinositol-3-phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • enzyme binding • platelet-derived growth factor receptor binding • GO:0001948, GO:0016582 Ikatan protein plasma • protein kinase binding • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity • anaphase-promoting complex binding • pengikatan protein identik • hydrolase activity • lipid binding • ubiquitin-specific protease binding • ionotropic glutamate receptor binding • protein tyrosine kinase binding • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity • PDZ domain binding
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Komponen seluler | • sitoplasma • postsynaptic membrane • extracellular region • mitokondria • neuron projection • cytoplasmic side of plasma membrane • Inti sel • cell projection • dendritic spine • myelin sheath adaxonal region • Schmidt-Lanterman incisure • membran plasma apikal • Membran sel • PML body • nucleoplasm • sitosol • postsynaptic cytosol
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Proses biologis | • multicellular organismal response to stress • regulation of neuron projection development • response to zinc ion • positive regulation of TRAIL-activated apoptotic signaling pathway • response to organic substance • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of B cell apoptotic process • Angiogenesis • positive regulation of ERK1 and ERK2 cascade • negative regulation of epithelial cell proliferation • long-term depression • positive regulation of excitatory postsynaptic potential • cell population proliferation • response to ethanol • neuron projection development • respons seluler terhadap hipoksia • negative regulation of cell size • negative regulation of cell population proliferation • prepulse inhibition • regulation of myeloid cell apoptotic process • male mating behavior • locomotory behavior • dentate gyrus development • positive regulation of apoptotic signaling pathway • inositol phosphate metabolic process • response to arsenic-containing substance • Ingatan • forebrain morphogenesis • dendritic spine morphogenesis • heart development • central nervous system development • negative regulation of axonogenesis • regulation of cellular localization • synapse maturation • belajar atau mengingat • perilaku sosial • Sinaptogenesis • cellular response to decreased oxygen levels • prostate gland growth • platelet-derived growth factor receptor signaling pathway • negative regulation of dendritic spine morphogenesis • brain morphogenesis • GO:0033128 negative regulation of protein phosphorylation • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cellular component size • response to nutrient • negative regulation of synaptic vesicle clustering • postsynaptic density assembly • GO:0016576 protein dephosphorylation • protein stabilization • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • response to glucose • perkembangan sistem saraf • adult behavior • phosphatidylinositol dephosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • response to inorganic substance • canonical Wnt signaling pathway • phosphatidylinositol biosynthetic process • negative regulation of organ growth • negative regulation of ribosome biogenesis • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • locomotor rhythm • central nervous system myelin maintenance • regulation of axon regeneration • response to estradiol • response to ATP • negative regulation of phagocytosis • GO:1904578 response to organic cyclic compound • protein kinase B signaling • cardiac muscle tissue development • metabolisme lipid • GO:0010260 penuaan • neuron-neuron synaptic transmission • negative regulation of excitatory postsynaptic potential • presynaptic membrane assembly • regulation of cell cycle • maternal behavior • rhythmic synaptic transmission • positive regulation of cell population proliferation • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • Migrasi sel • negative regulation of myelination • inositol phosphate dephosphorylation • regulation of synaptic transmission, GABAergic • endothelial cell migration • central nervous system neuron axonogenesis • long-term potentiation • peptidyl-tyrosine dephosphorylation • negative regulation of axon regeneration • negative regulation of cardiac muscle cell proliferation • GO:0090623, GO:1903835, GO:0007092, GO:0051488, GO:0051487 positive regulation of ubiquitin protein ligase activity • protein deubiquitination • negative regulation of epithelial to mesenchymal transition • negative regulation of keratinocyte migration • cellular response to electrical stimulus • negative regulation of wound healing, spreading of epidermal cells • negative regulation of phosphatidylinositol 3-kinase signaling • GO:1901313 positive regulation of gene expression • positive regulation of cardiac muscle cell apoptotic process • response to activity • cellular response to insulin stimulus • cellular response to leptin stimulus • positive regulation of neuron differentiation • cellular response to ethanol • negative regulation of potassium ion transmembrane transporter activity • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • negative regulation of signaling receptor activity • negative regulation of protein kinase B signaling • GO:0097285 Apoptosis • negative regulation of cell migration • regulation of protein stability • negative regulation of focal adhesion assembly • negative regulation of vascular associated smooth muscle cell proliferation • transcription initiation from RNA polymerase II promoter • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of neuron projection development
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Sumber:Amigo / QuickGO |
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Ortolog |
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Spesies | Manusia | Tikus |
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Entrez | | |
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Ensembl | |
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ENSG00000171862 ENSG00000284792 |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_000314 NM_001304717 NM_001304718 |
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RefSeq (protein) | |
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NP_000305 NP_001291646 NP_001291647 NP_000305.3 |
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Lokasi (UCSC) | Chr 10: 87.86 – 87.97 Mb | Chr 19: 32.73 – 32.8 Mb |
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Pencarian PubMed | [3] | [4] |
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Wikidata |
Lihat/Sunting Manusia | Lihat/Sunting Tikus |
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