ITPR1

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Inositol 1,4,5-trisphosphate receptor, type 1
PDB rendering based on 1n4k.
Estruturas disponíveis
PDB Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB

1n4k, 1xzz

Identificadores
Símbolos ITPR1; ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94; SCA15; SCA16; SCA29
IDs externos OMIM: 147265 MGI: 96623 HomoloGene: 1673 IUPHAR: IP3R1 ChEMBL: 4046 GeneCards: ITPR1 Gene
Ontologia do gene
Função molecular •intracellular ligand-gated calcium channel activity
•inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
•protein binding
•calcium ion transmembrane transporter activity
•phosphatidylinositol binding
Componente celular •nuclear inner membrane
•nucleolus
•endoplasmic reticulum
•endoplasmic reticulum membrane
•calcineurin complex
•postsynaptic density
•membrane
•integral component of membrane
•sarcoplasmic reticulum
•platelet dense granule membrane
•platelet dense tubular network
•platelet dense tubular network membrane
Processo biológico •response to hypoxia
•energy reserve metabolic process
•calcium ion transport
•signal transduction
•epidermal growth factor receptor signaling pathway
•activation of phospholipase C activity
•blood coagulation
•fibroblast growth factor receptor signaling pathway
•post-embryonic development
•platelet activation
•endoplasmic reticulum calcium ion homeostasis
•Fc-epsilon receptor signaling pathway
•Fc-gamma receptor signaling pathway involved in phagocytosis
•small molecule metabolic process
•innate immune response
•neurotrophin TRK receptor signaling pathway
•inositol phosphate-mediated signaling
•regulation of insulin secretion
•voluntary musculoskeletal movement
•release of sequestered calcium ion into cytosol
•intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
•calcium ion transmembrane transport
Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies Humano Rato
Entrez 3708 16438
Ensembl ENSG00000150995 ENSMUSG00000030102
UniProt Q14643 P11881
RefSeq (mRNA) NM_001099952 NM_010585
RefSeq (proteína) NP_001093422 NP_034715
Localização (UCSC) Chr 3:
4.54 – 4.89 Mb		 Chr 6:
108.21 – 108.55 Mb
Busca PubMed [1] [2]
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ITPR1 (do inglês, inositol 1,4,5-triphosphate receptor, type 1) é uma proteína que é codificada pelo gene humano ITPR1.[1][2][3][4][5]

Ver também

Referências

  1. ↑ Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guenet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T; et al. (1994). «Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization». Biochem J. 302 ( Pt 3): 781–90. PMC 1137299Acessível livremente. PMID 7945203  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  2. ↑ Nucifora FC Jr, Li SH, Danoff S, Ullrich A, Ross CA (1996). «Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant». Brain Res Mol Brain Res. 32 (2): 291–6. PMID 7500840. doi:10.1016/0169-328X(95)00089-B  !CS1 manut: Nomes múltiplos: lista de autores (link)
  3. ↑ van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (2007). «Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans». PLoS Genet. 3 (6): e108. PMC 1892049Acessível livremente. PMID 17590087. doi:10.1371/journal.pgen.0030108  !CS1 manut: Nomes múltiplos: lista de autores (link)
  4. ↑ Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (2008). «Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16». J Med Genet. 45 (1): 32–5. PMID 17932120. doi:10.1136/jmg.2007.053942  !CS1 manut: Nomes múltiplos: lista de autores (link)
  5. ↑ «Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1» 

Leitura de apoio

  • Stove V, Verhasselt B (2006). «Modelling thymic HIV-1 Nef effects.». Curr. HIV Res. 4 (1): 57–64. PMID 16454711. doi:10.2174/157016206775197583 
  • Joseph SK, Lin C, Pierson S; et al. (1995). «Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.». J. Biol. Chem. 270 (40): 23310–6. PMID 7559486. doi:10.1074/jbc.270.40.23310  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Harnick DJ, Jayaraman T, Ma Y; et al. (1995). «The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.». J. Biol. Chem. 270 (6): 2833–40. PMID 7852357. doi:10.1074/jbc.270.6.2833  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Wojcikiewicz RJ, Furuichi T, Nakade S; et al. (1994). «Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation.». J. Biol. Chem. 269 (11): 7963–9. PMID 8132516  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Komalavilas P, Lincoln TM (1994). «Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.». J. Biol. Chem. 269 (12): 8701–7. PMID 8132598 
  • Cameron AM, Steiner JP, Roskams AJ; et al. (1996). «Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.». Cell. 83 (3): 463–72. PMID 8521476. doi:10.1016/0092-8674(95)90124-8  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Yan J, Khanna KK, Lavin MF (1996). «Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation.». Int. J. Radiat. Biol. 69 (5): 539–46. PMID 8648241. doi:10.1080/095530096145544  !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Quinton TM, Dean WL (1996). «Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets.». Biochem. Biophys. Res. Commun. 224 (3): 740–6. PMID 8713116. doi:10.1006/bbrc.1996.1093 
  • Cameron AM, Nucifora FC, Fung ET; et al. (1997). «FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.». J. Biol. Chem. 272 (44): 27582–8. PMID 9346894. doi:10.1074/jbc.272.44.27582  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Deelman LE, Jonk LJ, Henning RH (1998). «The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor.». Gene. 207 (2): 219–25. PMID 9511764. doi:10.1016/S0378-1119(97)00630-6  !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Martin C, Chapman KE, Seckl JR, Ashley RH (1998). «Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.». Neuroscience. 85 (1): 205–16. PMID 9607712. doi:10.1016/S0306-4522(97)00612-X  !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Tu JC, Xiao B, Yuan JP; et al. (1998). «Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.». Neuron. 21 (4): 717–26. PMID 9808459. doi:10.1016/S0896-6273(00)80589-9  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Kiselyov K, Xu X, Mozhayeva G; et al. (1998). «Functional interaction between InsP3 receptors and store-operated Htrp3 channels.». Nature. 396 (6710): 478–82. PMID 9853757. doi:10.1038/24890  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Lin P, Yao Y, Hofmeister R; et al. (1999). «Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi.». J. Cell Biol. 145 (2): 279–89. PMC 2133108Acessível livremente. PMID 10209024. doi:10.1083/jcb.145.2.279  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Schlossmann J, Ammendola A, Ashman K; et al. (2000). «Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.». Nature. 404 (6774): 197–201. PMID 10724174. doi:10.1038/35004606  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). «Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.». Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMC 16267Acessível livremente. PMID 10737800. doi:10.1073/pnas.97.7.3491  !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). «Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.». J. Immunol. 164 (12): 6538–42. PMID 10843712  !CS1 manut: Nomes múltiplos: lista de autores (link)
  • Tanimura A, Tojyo Y, Turner RJ (2000). «Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.». J. Biol. Chem. 275 (35): 27488–93. PMID 10874040. doi:10.1074/jbc.M004495200  !CS1 manut: Nomes múltiplos: lista de autores (link)

Ligações externas

  • MeSH ITPR1+protein,+human