BD-1063

(IUPAC) ime

1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine

Klinički podaci

Identifikatori

CAS broj

150208-28-9

ATC kod

nije dodeljen

PubChem^[1]^[2]

574780

Hemijski podaci

Formula

C₁₃H₁₈Cl₂N₂

Mol. masa

273.201 g/mol

SMILES

eMolekuli & PubHem

InChI
InChI=1S/C13H18Cl2N2/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11/h2-3,10H,4-9H2,1H3^Y Key: SUIZRDJCBVPASY-UHFFFAOYSA-N^Y

Farmakoinformacioni podaci

Trudnoća

Pravni status

BD-1063 je antagonist sigma receptora koji je selektivan za σ₁ tip. On blokira MDMA efekte u studijama na životinjama,^[3] i umanjuje unos alkohola u modelima alkoholizma.^[4]

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Brammer MK, Gilmore DL, Matsumoto RR (December 2006). „Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors”. European Journal of Pharmacology 553 (1-3): 141–5. DOI:10.1016/j.ejphar.2006.09.038. PMC 1780037. PMID 17070798.
↑ Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP (May 2009). „The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking”. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 34 (6): 1482–93. DOI:10.1038/npp.2008.192. PMC 2669694. PMID 18946467.