Dualno specifična kinaza
| Dualno specifična kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.12.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dualno specifična kinaza (EC 2.7.12.1, ADK1, Arabidopsis dualno specifična kinaza 1, CLK1, dDYRK2, Mps1p) je enzim sa sistematskim imenom ATP:protein fosfotransferaza (Ser/Thr- and Tyr-fosforilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + protein ADP + fosfoprotein
Ova familija enzima može da fosforiliše Ser/Thr i Tyr ostatke.
Reference
- ↑ Ali, N., Halfter, U. and Chua, N.H. (1994). „Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine”. J. Biol. Chem. 269: 31626-31629. PMID 7527390.
- ↑ Lauze, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R. and Winey, M. (1995). „Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase”. EMBO J. 14: 1655-1663. PMID 7737118.
- ↑ Menegay, H.J., Myers, M.P., Moeslein, F.M. and Landreth, G.E. (2000). „Biochemical characterization and localization of the dual specificity kinase CLK1”. J. Cell Sci. 113: 3241-3253. PMID 10954422.
- ↑ Lochhead, P.A., Sibbet, G., Kinstrie, R., Cleghon, T., Rylatt, M., Morrison, D.K. and Cleghon, V. (2003). „dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila”. Biochem. J. 374: 381-391. PMID 12786602.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Dual-specificity+kinase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
