MST1R

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Makrofagno stimulišući receptor 1 (c-met srodna tirozinska kinaza)
Dostupne strukture
3PLS, 4FWW
Identifikatori
SimboliMST1R; CD136; CDw136; PTK8; RON
Vanjski IDOMIM: 600168 MGI: 99614 HomoloGene: 1835 GeneCards: MST1R Gene
EC broj2.7.10.1
Ontologija gena
Molekulska funkcija • aktivnost receptora faktora stimulacije makrofagne kolonije
• proteinsko vezivanje
• ATP vezivanje
Ćelijska komponenta • stres fiber
• integralna komponenta ćelijske membrane
Biološki proces • komponenta ćelijskog kretanja
• odbrambeni respons
• prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez448619882
EnsemblENSG00000164078ENSMUSG00000032584
UniProtQ04912Q62190
Ref. Sekv. (iRNK)NM_001244937NM_001287261
Ref. Sekv. (protein)NP_001231866NP_001274190
Lokacija (UCSC)Chr 3:
49.92 - 49.94 Mb		Chr 9:
107.91 - 107.92 Mb
PubMed pretraga[1][2]

Makrofagno stimulišući proteinski receptor je protein koji je kod ljudi kodiran MST1R genom.[1][2] MST1R je takođe poznat kao RON (Recepteur d'Origine Nantais) kinaza, pri čemu ime potiče od francuskog grada u kome je otkriven. On je srodan sa c-MET receptorskom tirozinsko kinazom.[1][3]

Interakcije

MST1R formira interakcije sa Grb2.[4][5]

Reference

  1. ↑ 1,0 1,1 Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). „A novel putative receptor protein tyrosine kinase of the met family”. Oncogene 8 (5): 1195–202. PMID 8386824.  Greška u referenci: Nevaljana oznaka <ref>; naziv "pmid8386824" je zadan više puta s različitim sadržajem
  2. ↑ „Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)”. 
  3. ↑ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). „RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP”. EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829. 
  4. ↑ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). „Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor”. Biochem. Biophys. Res. Commun. 216 (1): 110–8. DOI:10.1006/bbrc.1995.2598. PMID 7488076. 
  5. ↑ Iwama A, Yamaguchi N, Suda T (November 1996). „STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family”. EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464. 

Literatura

  • Li BQ, Wang MH, Kung HF, et al. (1995). „Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor”. Biochem. Biophys. Res. Commun. 216 (1): 110–8. DOI:10.1006/bbrc.1995.2598. PMID 7488076. 
  • Wang MH, Ronsin C, Gesnel MC, et al. (1994). „Identification of the ron gene product as the receptor for the human macrophage stimulating protein”. Science 266 (5182): 117–9. DOI:10.1126/science.7939629. PMID 7939629. 
  • Gaudino G, Follenzi A, Naldini L, et al. (1994). „RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP”. EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829. 
  • Lee ST, Strunk KM, Spritz RA (1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes”. Oncogene 8 (12): 3403–10. PMID 8247543. 
  • Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). „A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype”. Mol. Cell. Biol. 16 (10): 5518–26. PMC 231551. PMID 8816464. 
  • Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548. 
  • Iwama A, Yamaguchi N, Suda T (1997). „STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family”. EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464. 
  • Sakamoto O, Iwama A, Amitani R, et al. (1997). „Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility”. J. Clin. Invest. 99 (4): 701–9. DOI:10.1172/JCI119214. PMC 507853. PMID 9045873. 
  • Follenzi A, Bakovic S, Gual P, et al. (2000). „Cross-talk between the proto-oncogenes Met and Ron”. Oncogene 19 (27): 3041–9. DOI:10.1038/sj.onc.1203620. PMID 10871856. 
  • Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). „Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo”. Oncogene 21 (41): 6382–6. DOI:10.1038/sj.onc.1205783. PMID 12214279. 
  • Chen YQ, Zhou YQ, Fu LH, et al. (2002). „Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais”. Carcinogenesis 23 (11): 1811–9. DOI:10.1093/carcin/23.11.1811. PMID 12419829. 
  • Zhou YQ, He C, Chen YQ, et al. (2003). „Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential”. Oncogene 22 (2): 186–97. DOI:10.1038/sj.onc.1206075. PMID 12527888. 
  • Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). „Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580–5. DOI:10.1073/pnas.0837136100. PMC 153598. PMID 12676986. 
  • Rampino T, Gregorini M, Soccio G, et al. (2003). „The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma”. Am. J. Surg. Pathol. 27 (6): 779–85. DOI:10.1097/00000478-200306000-00008. PMID 12766581. 
  • Penengo L, Rubin C, Yarden Y, Gaudino G (2003). „c-Cbl is a critical modulator of the Ron tyrosine kinase receptor”. Oncogene 22 (24): 3669–79. DOI:10.1038/sj.onc.1206585. PMID 12802274. 
  • Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). „The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness”. Exp. Cell Res. 288 (2): 382–9. DOI:10.1016/S0014-4827(03)00250-7. PMID 12915129. 
  • Santoro MM, Gaudino G, Marchisio PC (2003). „The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration”. Dev. Cell 5 (2): 257–71. DOI:10.1016/S1534-5807(03)00201-6. PMID 12919677. 
  • Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). „The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation”. J. Biol. Chem. 279 (5): 3726–32. DOI:10.1074/jbc.M309342200. PMID 14597639. 
  • van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). „Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors”. Blood 103 (12): 4457–65. DOI:10.1182/blood-2003-08-2713. PMID 14982882. 
  • Raeppel S, Gaudette G, et al. (2010). „Identification of a novel series of potent RON receptor tyrosine kinase inhibitors”. Bioorg. Med. Chem. Lett. 20 (9): 2745–9. DOI:10.1016/j.bmcl.2010.03.073. 
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