Piroglutamilna peptidaza I
| Piroglutamilna peptidaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.3 | ||||||||
| CAS broj | 9075-21-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Piroglutamilna peptidaza I (EC 3.4.19.3, 5-oksoprolilna peptidaza, piraza, piroglutamatna aminopeptidaza, piroglutamilna aminopeptidaza, L-piroglutamil peptidna hidrolaza, pirolidon-karboksilna peptidaza, pirolidon-karboksilatna peptidaza, pirolidonilna peptidaza, L-pirolidonkarboksilatna peptidaza, piroglutamidaza, pirolidonkarboksilol peptidaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje N-terminalne piroglutamilne grupe sa polipeptida, pri čemu druga aminokiselina generalno nije Pro
Ovaj cisteinska peptidaza, je izolovana iz bakterija, biljki i životinja.
Reference
- ↑ Tsuru, D., Nakamura, K., Yoshimoto, T. and Fujiwara, K. (1984). „Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme”. Biochim. Biophys. Acta 791: 117-122.
- ↑ Awadé, A.C., Cleuziat, P., Gonzalès, T. and Robert-Baudouy, J. (1994). „Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins”. Proteins: Struct. Funct. Genet. 20: 34-51. PMID 7824521.
- ↑ Patti, J.M., Schneider, A., Garza, N. and Boles, J.O. (1995). „Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus'”. Gene 166: 95-99. PMID 8529900.
- ↑ Le Saux, O., Gonzalès, T. and Robert-Baudouy, J. (1996). „Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase”. J. Bacteriol. 178: 3308-3313. PMID 8655512.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Pyroglutamyl-peptidase+I
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
