Propentofilin
 | |||
| (IUPAC) ime | |||
|---|---|---|---|
| 3-metil-1-(5-oksoheksil)-7-propil-3,7-dihidro-1H-purin-2,6-dion | |||
| Klinički podaci | |||
| AHFS/Drugs.com | Internacionalno ime leka | ||
| Identifikatori | |||
| CAS broj | 55242-55-2 | ||
| ATC kod | N06BC02 QC04AD90 | ||
| PubChem[1][2] | 4938 | ||
| UNII | 5RTA398U4H  Y | ||
| Hemijski podaci | |||
| Formula | C15H22N4O3 | ||
| Mol. masa | 306,360 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Propentofilin (HWA 285) je ksantinski derivat sa mogućim neuroprotektivnim dejstvom.
Farmakologija
On je inhibitor fosfodiesteraze.[3] On takođe deluje kao inhibitor preuzimanja adenozina.[4][5][6]
Upotreba
On je izučavan za moguću primenu u tretiranju Alchajimerove bolesti i vaskularne demencije.[7][8]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.
- ↑ Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.
- ↑ Salimi S, Fotouhi A, Ghoreishi A i dr.. (April 2008). „A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia”. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (3): 726–732. DOI:10.1016/j.pnpbp.2007.11.021. PMID 18096287.
- ↑ Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998). „Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet”. Neuroscience 84 (4): 1127–1133. DOI:10.1016/S0306-4522(97)00542-3. PMID 9578400.
- ↑ Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane database of systematic reviews (Online) (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.
- ↑ Kittner B, Rössner M, Rother M (1997). „Clinical trials in dementia with propentofylline”. Ann. N. Y. Acad. Sci. 826: 307–316. DOI:10.1111/j.1749-6632.1997.tb48481.x. PMID 9329701.
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Inhibitori fosfodiesteraze
MMPX • SCH-51866 • Vinpocetin
BAY 60-7550 • EHNA
Amrinon • Anagrelid • Bukladezin • Cilostamid • Cilostazol • Enoksimon • KMUP-1 • Milrinon • Kvazinon • RPL-554 • Siguazodan • Trekvinsin • Vesnarinon • Zardaverin
Arofilin • Cilomilast • CP-80633 • Denbutilin • Drotaverin • Etazolat • Filaminast • Glaucin • HT-0712 • Ibudilast • ICI-63197 • Irsogladin • Luteolin • Mesembrin • Piklamilast • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976
Acetildenafil • Aildenafil • Avanafil • Dipiridamol • Ikariin • Lodenafil • Mirodenafil • MY-5445 • Nitrozoprodenafil • Sildenafil • Sulfoaildenafil • T-0156 • Tadalafil • Udenafil • Vardenafil
BAY 73-6691 • SCH-51866
