RGS13
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| Regulator G-proteinske signalizacije 13 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | RGS13; MGC17173 | ||||||||||
| Vanjski ID | OMIM: 607190 MGI: 2180585 HomoloGene: 14774 GeneCards: RGS13 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6003 | 246709 | |||||||||
| Ensembl | ENSG00000127074 | ENSMUSG00000051079 | |||||||||
| UniProt | O14921 | Q8K443 | |||||||||
| Ref. Sekv. (iRNK) | NM_002927 | NM_153171 | |||||||||
| Ref. Sekv. (protein) | NP_002918 | NP_694811 | |||||||||
| Lokacija (UCSC) | Chr 1: 192.61 - 192.63 Mb | Chr 1: 144.14 - 144.18 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Regulator G-proteinske signalizacije 13 je protein koji je kod ljudi kodiran RGS13 genom.[1][2]
RGS 13 je član R4 potfamilije RGS (Regualtori G proteinske signalizacije) proteina koji imaju kratke peptidne sekvence pored RGS domena. RGS 13 supresuje imunoglobulinom E- posredovane alergijske response.[3]
Reference
- ↑ Johnson EN, Druey KM (May 2002). „Functional characterization of the G protein regulator RGS13”. J Biol Chem 277 (19): 16768–16774. DOI:10.1074/jbc.M200751200. PMID 11875076.
- ↑ „Entrez Gene: RGS13 regulator of G-protein signalling 13”.
- ↑ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). „Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13”. Nat. Immunol. 9 (1): 73–80. DOI:10.1038/ni1533. PMC 2387203. PMID 18026105.
Literatura
- Gregory SG, Barlow KF, McLay KE i dr.. (2006). „The DNA sequence and biological annotation of human chromosome 1”. Nature 441 (7091): 315–321. DOI:10.1038/nature04727. PMID 16710414.
- Han JI, Huang NN, Kim DU, Kehrl JH (2006). „RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization”. J. Leukoc. Biol. 79 (6): 1357–1368. DOI:10.1189/jlb.1105693. PMID 16565322.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–2127. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Islam TC, Asplund AC, Lindvall JM i dr.. (2003). „High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma”. Leukemia 17 (9): 1880–1890. DOI:10.1038/sj.leu.2403057. PMID 12970790.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sierra DA, Gilbert DJ, Householder D i dr.. (2002). „Evolution of the regulators of G-protein signaling multigene family in mouse and human”. Genomics 79 (2): 177–185. DOI:10.1006/geno.2002.6693. PMID 11829488.
- Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). „Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family”. Nature 379 (6567): 742–746. DOI:10.1038/379742a0. PMID 8602223.
References
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Monomerni | |
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Heterotrimeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
