GNG13

Vezujući protein guaninskog nukleotida (G protein), gama 13
Identifikatori
Simboli GNG13; G(gamma)13; h2-35
Vanjski ID OMIM: 607298 HomoloGene: 81890 GeneCards: GNG13 Gene
Ontologija gena
Molekularna funkcija • aktivnost prenosa signala
Celularna komponenta • heterotrimerni kompleks G-proteina
• ćelijska membrana
Biološki proces • metabolički proces energijske rezerve
• signalni put G-protein spregnutog receptora koji aktivira fosfolipazu C
• metabolički proces malih molekula
• sensorna percepcija ukusa
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 51764 64337
Ensembl ENSG00000127588 ENSMUSG00000025739
UniProt Q9P2W3 Q9JMF3
RefSeq (mRNA) NM_016541.2 NM_022422.5
RefSeq (protein) NP_057625.1 NP_071867.1
Lokacija (UCSC) Chr 16:
0.85 - 0.85 Mb		 Chr 17:
25.85 - 25.86 Mb
PubMed pretraga [1] [2]

Vezujući protein guaninskog nukleotida G(I)/G(S)/G(O) podjedinica gama-13 je protein koji je kod ljudi kodiran GNG13 genom.[1][2]

Interakcije

GNG13 formira interakcije sa GNB5.[3]

Reference

  1. ^ Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF (2000). „Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium”. Nat Neurosci. 2 (12): 1055—62. PMID 10570481. doi:10.1038/15981. 
  2. ^ „Entrez Gene: GNG13 guanine nucleotide binding protein (G protein), gamma 13”. 
  3. ^ Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (2001). „G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)”. J. Biol. Chem. United States. 276 (52): 49267—74. ISSN 0021-9258. PMID 11675383. doi:10.1074/jbc.M106565200. 

Literatura

  • Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791. 
  • Daniels RJ; Peden JF; Lloyd C; et al. (2001). „Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.”. Hum. Mol. Genet. 10 (4): 339—52. PMID 11157797. doi:10.1093/hmg/10.4.339. 
  • Blake BL; Wing MR; Zhou JY; et al. (2002). „G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13).”. J. Biol. Chem. 276 (52): 49267—74. PMID 11675383. doi:10.1074/jbc.M106565200. 
  • Huang L; Max M; Margolskee RF; et al. (2003). „G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells.”. J. Comp. Neurol. 455 (1): 1—10. PMID 12454992. doi:10.1002/cne.10396. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Cuello F; Schulze RA; Heemeyer F; et al. (2003). „Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.”. J. Biol. Chem. 278 (9): 7220—6. PMID 12486123. doi:10.1074/jbc.M210304200. 
  • Kato C; Mizutani T; Tamaki H; et al. (2004). „Characterization of heterotrimeric G protein complexes in rice plasma membrane.”. Plant J. 38 (2): 320—31. PMID 15078334. doi:10.1111/j.1365-313X.2004.02046.x. 
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 
  • Martin J; Han C; Gordon LA; et al. (2005). „The sequence and analysis of duplication-rich human chromosome 16.”. Nature. 432 (7020): 988—94. PMID 15616553. doi:10.1038/nature03187. 
  • Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55—65. PMC 1356129 Слободан приступ. PMID 16344560. doi:10.1101/gr.4039406. 
  • Li Z, Benard O, Margolskee RF (2006). „Ggamma13 interacts with PDZ domain-containing proteins.”. J. Biol. Chem. 281 (16): 11066—73. PMID 16473877. doi:10.1074/jbc.M600113200.