MAP3K14

Mitogenom-aktivirana protein kinaza kinaza kinaza 14
Identifikatori
Simboli MAP3K14; FTDCR1B; HS; HSNIK; NIK
Vanjski ID OMIM: 604655 MGI: 1858204 HomoloGene: 2940 GeneCards: MAP3K14 Gene
EC broj 2.7.11.25
Ontologija gena
Molekularna funkcija • nukleotidno vezivanje
• aktivnost proteinske kinaze
• aktivnost proteinske serin/treonin kinaze
• proteinsko vezivanje
• ATP vezivanje
• aktivnost transferaze
Biološki proces • fosforilacija proteinskih aminokiselina
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 9020 53859
Ensembl ENSG00000006062 ENSMUSG00000020941
UniProt Q99558 Q544K4
RefSeq (mRNA) NM_003954 NM_016896
RefSeq (protein) NP_003945 NP_058592
Lokacija (UCSC) Chr 17:
40.7 - 40.75 Mb		 Chr 11:
103.04 - 103.08 Mb
PubMed pretraga [1] [2]

MAP3K14 (Mitogenom-aktivirana protein kinaza kinaza kinaza 14, NF-kapa-B-indukujuća kinaza, NIK), je enzim koji je kod čoveka kodiran MAP3K14 genom.[1][2]

Funkcija

Ovaj gen kodira mitogenom-activiranu kinaza kinaza kinazu 14, koja je serin/treonin-specifična proteinska kinaza. Ova kinaza se vezuje za TRAF2 i stimuliše NF-κB aktivnost. Ona je kritična kinaza alternativnog NF-κB aktivacionog puta. Njena sekvenca je slična sa nekoliko drugih MAPKK kinaza. Ona učestvuje u NF-κB-indukovanoj signalnoj kaskadi koja je zajednička za receptore TNF/NGF) familije i za interleukinski-1 tip-I receptor.[2]

Interakcije

Za MAP3K14 je pokazano da interaguje sa TRAF2,[3][4] IKK2[3][5] i CHUK.[3][6][7][8]

Reference

  1. ^ Malinin NL, Boldin MP, Kovalenko AV, Wallach D (1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature. 385 (6616): 540—4. PMID 9020361. doi:10.1038/385540a0. 
  2. ^ а б „Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14”. 
  3. ^ а б в Luftig, M A; Cahir-McFarland E; et al. (2001). „Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40”. J. Biol. Chem. United States. 276 (18): 14602—6. ISSN 0021-9258. PMID 11278268. doi:10.1074/jbc.C100103200. 
  4. ^ Malinin, N L; Boldin M P; et al. (1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature. ENGLAND. 385 (6616): 540—4. ISSN 0028-0836. PMID 9020361. doi:10.1038/385540a0. 
  5. ^ Woronicz, J D; Gao X; et al. (1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK”. Science. UNITED STATES. 278 (5339): 866—9. ISSN 0036-8075. PMID 9346485. doi:10.1126/science.278.5339.866. 
  6. ^ Régnier, C H; Song H Y; et al. (1997). „Identification and characterization of an IkappaB kinase”. Cell. UNITED STATES. 90 (2): 373—83. ISSN 0092-8674. PMID 9244310. doi:10.1016/S0092-8674(00)80344-X. 
  7. ^ Xiao, G; Sun S C (2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain”. J. Biol. Chem. UNITED STATES. 275 (28): 21081—5. ISSN 0021-9258. PMID 10887201. doi:10.1074/jbc.M002552200. 
  8. ^ Ninomiya-Tsuji, J; Kishimoto K; et al. (1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway”. Nature. ENGLAND. 398 (6724): 252—6. ISSN 0028-0836. PMID 10094049. doi:10.1038/18465. 

Literatura

  • Régnier CH; Song HY; Gao X; et al. (1997). „Identification and characterization of an IkappaB kinase.”. Cell. 90 (2): 373—83. PMID 9244310. doi:10.1016/S0092-8674(00)80344-X. 
  • Song HY; Régnier CH; Kirschning CJ; et al. (1997). „Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.”. Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792—6. PMC 23270 Слободан приступ. PMID 9275204. doi:10.1073/pnas.94.18.9792. 
  • Woronicz JD; Gao X; Cao Z; et al. (1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.”. Science. 278 (5339): 866—9. PMID 9346485. doi:10.1126/science.278.5339.866. 
  • Ling L, Cao Z, Goeddel DV (1998). „NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.”. Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3792—7. PMC 19916 Слободан приступ. PMID 9520446. doi:10.1073/pnas.95.7.3792. 
  • Lee FS, Peters RT, Dang LC, Maniatis T (1998). „MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.”. Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319—24. PMC 21336 Слободан приступ. PMID 9689078. doi:10.1073/pnas.95.16.9319. 
  • Lin X; Mu Y; Cunningham ET; et al. (1998). „Molecular determinants of NF-kappaB-inducing kinase action.”. Mol. Cell. Biol. 18 (10): 5899—907. PMC 109176 Слободан приступ. PMID 9742107. 
  • Cohen L, Henzel WJ, Baeuerle PA (1998). „IKAP is a scaffold protein of the IkappaB kinase complex.”. Nature. 395 (6699): 292—6. PMID 9751059. doi:10.1038/26254. 
  • Aronsson FC; Magnusson P; Andersson B; et al. (1998). „The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.”. Hum. Genet. 103 (3): 340—5. PMID 9799091. doi:10.1007/s004390050827. 
  • Nemoto S, DiDonato JA, Lin A (1998). „Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.”. Mol. Cell. Biol. 18 (12): 7336—43. PMC 109315 Слободан приступ. PMID 9819420. 
  • Li Y; Kang J; Friedman J; et al. (1999). „Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.”. Proc. Natl. Acad. Sci. U.S.A. 96 (3): 1042—7. PMC 15347 Слободан приступ. PMID 9927690. doi:10.1073/pnas.96.3.1042. 
  • Lallena MJ; Diaz-Meco MT; Bren G; et al. (1999). „Activation of IkappaB kinase beta by protein kinase C isoforms.”. Mol. Cell. Biol. 19 (3): 2180—8. PMC 84010 Слободан приступ. PMID 10022904. 
  • Lin X; Cunningham ET; Mu Y; et al. (1999). „The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.”. Immunity. 10 (2): 271—80. PMID 10072079. doi:10.1016/S1074-7613(00)80027-8. 
  • Ninomiya-Tsuji J; Kishimoto K; Hiyama A; et al. (1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.”. Nature. 398 (6724): 252—6. PMID 10094049. doi:10.1038/18465. 
  • Delhase M, Hayakawa M, Chen Y, Karin M (1999). „Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.”. Science. 284 (5412): 309—13. PMID 10195894. doi:10.1126/science.284.5412.309. 
  • Hu WH, Johnson H, Shu HB (1999). „Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways.”. J. Biol. Chem. 274 (43): 30603—10. PMID 10521444. doi:10.1074/jbc.274.43.30603. 
  • Yamamoto Y, Yin MJ, Gaynor RB (2000). „IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.”. Mol. Cell. Biol. 20 (10): 3655—66. PMC 85658 Слободан приступ. PMID 10779355. doi:10.1128/MCB.20.10.3655-3666.2000. 
  • Xiao G, Sun SC (2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain.”. J. Biol. Chem. 275 (28): 21081—5. PMID 10887201. doi:10.1074/jbc.M002552200. 
  • Chaudhary PM; Eby MT; Jasmin A; et al. (2000). „Activation of the NF-kappaB pathway by caspase 8 and its homologs.”. Oncogene. 19 (39): 4451—60. PMID 11002417. doi:10.1038/sj.onc.1203812. 
  • Kumar A; Eby MT; Sinha S; et al. (2001). „The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.”. J. Biol. Chem. 276 (4): 2668—77. PMID 11035039. doi:10.1074/jbc.M008356200. 
  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

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(1) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.1-EC 2.7.11.20)
Nespecifična serin/treonin proteinske kinaze (EC 2.7.11.1)
LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Proteinska kinaza B (AKT1, AKT2, AKT3), Ataksija telangiektazija mutirani, Sisarski cilj rapamicina, EIF-2 kinaze (PKR, HRI), Wee1 (WEE1)
Piruvat dehidrogenazna kinaza (EC 2.7.11.2)
Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3)
AMP-activated protein kinase,
(3-metil-2-oksobutanoat dehidrogenaza (prenos acetila)) (EC 2.7.11.4)
BCKDK, BCKDHA, BCKDHB
(izocitrat dehidrogenaza (NADP+)) kinaza (EC 2.7.11.5)
IDH2, IDH3A, IDH3B, IDH3G
tirozin 3-monooksigenazna kinaza (EC 2.7.11.6)
Miozin-teški-lanac kinaza (EC 2.7.11.7)
Aurora kinaza (Aurora A kinaza, Aurora B kinaza)
Fas-aktivirana serin/treoninska kinaza (EC 2.7.11.8)
Goodpasture-antigen-vezujuća proteinska kinaza (EC 2.7.11.9)
-
IκB kinaza (EC 2.7.11.10)
CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP
cAMP-zavisna proteinska kinaza (EC 2.7.11.11)
Proteinska kinaza A, PRKACG, PRKACB, PRKACA, PRKY
cGMP-zavisna proteinska kinaza (EC 2.7.11.12)
Protein kinaza C (EC 2.7.11.13)
Protein kinaza C, Protein kinaza Cζ, PKC alfa, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Proteinska zavisna proteinska N1, PKN2, PKN3,
Rodopsinska kinaza (EC 2.7.11.14)
Beta adrenergički receptor kinaza (EC 2.7.11.15)
Beta adrenergički receptor kinaza, Beta adrenergički receptor kinaza-2
G protein spregnuti receptor kinaza (EC 2.7.11.16)
GRK4, GRK5, GRK6
Ca2+/kalmodulin-zavisna (EC 2.7.11.17)
BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1
Miozin laki-lanac kinaza (EC 2.7.11.18)
MYLK, MYLK2, MYLK3, MYLK4
Fosforilazna kinaza (EC 2.7.11.19)
PHKA1, PHKA2, PHKB, PHKG1, PHKG2
Faktor elongacije 2 kinaza (EC 2.7.11.20)
Polo kinaza (EC 2.7.11.21)
PLK1, PLK2, PLK3, PLK4
(2) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.21-EC 2.7.11.30)
Polo kinaza (EC 2.7.11.21)
PLK1, PLK2, PLK3, PLK4
Ciklin-zavisna kinaza (EC 2.7.11.22)
CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1
(RNK-polimerazna)-podjedinica kinaza (EC 2.7.11.23)
RPS6KA5, RPS6KA4, P70S6 kinaza, P70-S6 kinaza 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1
Mitogenom-aktivirana proteinska kinaza (EC 2.7.11.24)
Ekstracelularnim signalom regulisane (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogenom-aktivirani protein (MAPK11, MAPK13, MAPK14)
MAP3K (EC 2.7.11.25)
MAP kinaza kinaza kinaze (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLK (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14
Tau-proteinska kinaza (EC 2.7.11.26)
TPK1, TTK, GSK-3
acetil-CoA karboksilazna kinaza] (EC 2.7.11.27)
-
Tropomiozinska kinaza (EC 2.7.11.28)
-
Receptor lipoproteina-niske-gustine kinaza (EC 2.7.11.29)
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Receptor protein serin/treonin kinaza (EC 2.7.11.30)
Koštani morfogenetski proteinski receptori (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Mulerianski hormonski receptor
(3) Kinaze dualne-specifičnosti (EC 2.7.12)
MAP2K
MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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