Mazindol : Osobine, Reference, Literatura, Spoljašnje veze Википедија

Mazindol

Mazindol
Klinički podaci


Prodajno ime	DEA No. 1605, Dimagrir, Magrilon, Mazanor
Drugs.com	Monografija
Farmakokinetički podaci
Poluvreme eliminacije	10-13 h

Identifikatori
CAS broj	22232-71-9^Y
ATC kod	A08AA05 (WHO)
PubChem	CID 4020
DrugBank	DB00579^Y
ChemSpider	3880^Y
ChEMBL	CHEMBL781^Y
Hemijski podaci
Formula	C₁₆H₁₃ClN₂O
Molarna masa	284,740
SMILES OC1(N2CCN=C2C2=CC=CC=C12)C1=CC=C(Cl)C=C1
InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2^Y Key:ZPXSCAKFGYXMGA-UHFFFAOYSA-N^Y

Mazindol je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu od 284,740 Da.^[1]^[2]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	1
Broj rotacionih veza	1
Particioni koeficijent^[3] (ALogP)	3,0
Rastvorljivost^[4] (logS, log(mol/L))	-3,9
Polarna površina^[5] (PSA, Å²)	35,8

^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. уреди
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.