Natrijum stiboglukonat

Natrijum stiboglukonat
Klinički podaci

Drugs.com	stibogluconate.html Monografija
Način primene	Intravenozno
Identifikatori
CAS broj	16037-91-5^Y
ATC kod	P01CB02 (WHO)
PubChem	CID 16685683
DrugBank	DB05630^Y
ChemSpider	21106382^Y
ChEBI	CHEBI:28148^Y
ChEMBL	CHEMBL367144^Y
Hemijski podaci
Formula	C₁₂H₃₅Na₃O₂₆Sb₂
Molarna masa	907,880
SMILES O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[H][C@@]1(O[Sb]2(O)(O[Sb]34([O-])O[C@@H](C([O-])=O)[C@@]([H])(O3)[C@]([H])(O4)[C@H](O)CO)O[C@@H](C([O-])=O)[C@@]1([H])O2)[C@H](O)CO
InChI InChI=1S/2C6H9O7.3Na.10H2O.2O.2Sb/c27-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h22-5,7-8H,1H2,(H,12,13);;;;101H2;;;;/q2-3;3+1;;;;;;;;;;;;-1;+3;+4/p-3/t22-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1^Y Key:YQDGWZZYGYKDLR-UZVLBLASSA-K^Y

Natrijum stiboglukonat je organsko jedinjenje, koje sadrži 12 atoma ugljenika i ima molekulsku masu od 907,880 Da.^[1]^[2]^[3]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	26
Broj donora vodonika	14
Broj rotacionih veza	8
Particioni koeficijent^[4] (ALogP)	-8,9
Rastvorljivost^[5] (logS, log(mol/L))	3,7
Polarna površina^[6] (PSA, Å²)	746,8

Reference

^ Murray HW, Berman JD, Davies CR, Saravia NG: Advances in leishmaniasis. Lancet. 2005 Oct 29-Nov 4. . 366 (9496): 1561—77 http://www.ncbi.nlm.nih.gov/pubmed/16257344. Недостаје или је празан параметар |title= (помоћ). PMID 16257344
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. уреди
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.