POLD4

Identifikatori

Alijasi

POLD4

Spoljašnji ID

OMIM: 611525 MGI: 1916995 HomoloGene: 10909 GeneCards: POLD4

Genska lokacija (miš)

Hr.	Chromosome 19 (mouse)^[1]

Band	19\|19 A	Start	4,281,953 bp^[1]
Band	19\|19 A	Kraj	4,283,688 bp^[1]

Genska ontologija
Molecular function	• GO:0001948, GO:0016582 везивање за протеине плазме • DNA-directed DNA polymerase activity
Cellular component	• delta DNA polymerase complex • Нуклеоплазма • Једарце • митохондрије • цитосол • једро
Biological process	• DNA-dependent DNA replication • nucleotide-excision repair, DNA gap filling • DNA synthesis involved in DNA repair • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • telomere maintenance • nucleotide-excision repair, DNA incision, 5'-to lesion • GO:0100026 поправка ДНК • cellular response to DNA damage stimulus • telomere maintenance via semi-conservative replication • репликација ДНК • DNA mismatch repair
Sources:Amigo / QuickGO

Ortolozi

Vrste

Čovek

Miš

Entrez


57804


69745

Ensembl


ENSG00000175482


ENSMUSG00000024854

UniProt


Q9HCU8


Q9CWP8

RefSeq (mRNA)


NM_001256870 NM_021173


NM_027196

RefSeq (protein)


NP_001243799 NP_066996


NP_081472

Location (UCSC)

n/a

Chr 19: 4.28 – 4.28 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Delta podjedinica 4 DNK polimeraze, takođe poznata kao delta podjedinica p12 DNK polimeraze, je protein koji je kod ljudi kodiran POLD4 genom.^[4] Ona je komponeneta kompleksa DNK polimeraze delta.

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000024854 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Entrez Gene: polymerase (DNA-directed)”.

Literatura

Xie B, Mazloum N, Liu L, et al. (2002). „Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.”. Biochemistry. 41 (44): 13133—42. PMID 12403614. doi:10.1021/bi0262707.
Selak N, Bachrati CZ, Shevelev I, et al. (2008). „The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.”. Nucleic Acids Res. 36 (16): 5166—79. PMC 2532730 . PMID 18682526. doi:10.1093/nar/gkn498.
Bae SH, Bae KH, Kim JA, Seo YS (2001). „RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.”. Nature. 412 (6845): 456—61. PMID 11473323. doi:10.1038/35086609.
Matsumoto Y, Kim K, Hurwitz J, et al. (1999). „Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.”. J. Biol. Chem. 274 (47): 33703—8. PMID 10559261. doi:10.1074/jbc.274.47.33703.
Liu G, Warbrick E (2006). „The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.”. Biochem. Biophys. Res. Commun. 349 (1): 360—6. PMID 16934752. doi:10.1016/j.bbrc.2006.08.049.
Tsurimoto T, Shinozaki A, Yano M, et al. (2005). „Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.”. Genes Cells. 10 (1): 13—22. PMID 15670210. doi:10.1111/j.1365-2443.2004.00812.x.
Wood RD, Shivji MK (1997). „Which DNA polymerases are used for DNA-repair in eukaryotes?”. Carcinogenesis. 18 (4): 605—10. PMID 9111189. doi:10.1093/carcin/18.4.605.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Huang QM, Akashi T, Masuda Y, et al. (2010). „Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells.”. Biochem. Biophys. Res. Commun. 391 (1): 542—6. PMID 19931513. doi:10.1016/j.bbrc.2009.11.094.
Li H, Xie B, Zhou Y, et al. (2006). „Functional roles of p12, the fourth subunit of human DNA polymerase delta.”. J. Biol. Chem. 281 (21): 14748—55. PMID 16510448. doi:10.1074/jbc.M600322200.
Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). „Identification of a fourth subunit of mammalian DNA polymerase delta.”. J. Biol. Chem. 275 (25): 18739—44. PMID 10751307. doi:10.1074/jbc.M001217200.

DNK replikacija (Prokariotska, Eukariotska)

Separacija
i inicijacija

Prokariotska (inicijacija)	Prereplikacioni kompleks Cdc6 Helikaza (dnaA, dnaB, T7) · Primaza (dnaG)
Eukariotska (priprema u G1 fazi)	Prereplikacioni kompleks: Kompleks prepoznavanja mesta početka (ORC1, ORC2, ORC3, ORC4, ORC5, ORC6) · Održavanje minihromozoma (MCM2 · MCM3 · MCM4 · MCM5 · MCM6 · MCM7) · CDC6 Faktor licenciranja Autonomna replikaciona sekvenca Protein jednolančanog vezivanja (SSBP1, SSBP2, SSBP3, SSBP4) RNaza H (RNASEH1, RNASEH2A) Helikaza: HFM1 Primaza: PRIM1 · PRIM2
Oba	Početak replikacije/Ori/Replikon Replikaciona viljuška (zaostajući i vodeći lanci) · Okazakijev fragment · Prajmer

Replikacija

Prokariotska (elongacija)	DNK polimeraza III holoenzim (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX, holA, holB, holC, holD, holE) · Replizom · DNK ligaza · DNK stega · Topoizomeraza (DNK giraza) Prokariotska DNK polimeraza: DNK polimeraza I (Klenov fragment)
Eukariotska (sinteza u S fazi)	Replikacioni faktor C (RFC1) · Endonukleaza prepusta (FEN1) · Topoizomeraza · Replikacioni protein A (RPA1) Eukariotska DNK polimeraza: delta (POLD1, POLD2, POLD3, POLD4) DNK stega (PCNA)
Oba	Kretanje: Procesivnost · DNK ligaza

Terminacija

Telomer: Telomeraza (TERT, TERC, DKC1)

B bsyn: dnk (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)