PPP1R9B

Protein fosfataza 1, regulatorna podjedinica 9B

PDB prikaz baziran na 2g5m.

Identifikatori

PPP1R9B; PPP1R6; PPP1R9; SPINO; Spn

Vanjski ID

OMIM: 603325 MGI: 2387581 HomoloGene: 32787 GeneCards: PPP1R9B Gene

Ontologija gena
Molekularna funkcija	• vezivanje aktina • inhibitor proteinske fosfataze • proteinsko vezivanje • vezivanje proteinske fosfataze 1
Celularna komponenta	• kompleks proteinske fosfataze tipa 1 • nukleus • nukleoplazma • citoplazma • citoskeleton • ćelijska membrana • adhezioni spoj • lamelipodijum • filopodijum • rufl membrana • dendritska izbočina • sinapsa
Biološki proces	• regulacija ćelijskog rasta ekstraćelijskim stimulusom • zaustavljanje ćelijskog ciklusa • regulacija ćelijske proliferacije • filopodijumska struktura • ćelijski respons na morfin • regulacija signalnog puta opioidnog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

84687

217124

Ensembl

ENSG00000108819

ENSMUSG00000038976

UniProt

Q96SB3

Q6R891

RefSeq (mRNA)

NM_032595.3

NM_172261.3

RefSeq (protein)

NP_115984.3

NP_758465.2

Lokacija (UCSC)

Chr 17:
45.57 - 45.58 Mb

Chr 11:
94.85 - 94.87 Mb

PubMed pretraga

[1]

[2]

Neurabin-2 je protein koji je kod ljudi kodiran PPP1R9B genom.^[1]^[2]

Spinofilin je regulatorni deo katalitičke jedinica proteinske fosfataze-1 (PP1). On je visoko izražen u dendritskim izbočinama, specijalizoanim delovima koji primaju veći deo ekscitatornog unosa u centralnom nervnom sistemu.^[2]

Interakcije

PPP1R9B formira interakcije sa PPP1CB,^[3] PPP1CA,^[3] Dopamine receptor D2,^[4] P16,^[5] PPP1CC,^[3]^[4] TIAM1^[6] i PPP1R2.^[7]

Reference

^ Allen PB, Ouimet CC, Greengard P (1997). „Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines”. Proc Natl Acad Sci U S A. 94 (18): 9956—61. PMC 23308 . PMID 9275233. doi:10.1073/pnas.94.18.9956.
^ ^а ^б „Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B”.
^ ^а ^б ^в Hsieh-Wilson, L C; Allen P B; et al. (1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1”. Biochemistry. UNITED STATES. 38 (14): 4365—73. ISSN 0006-2960. PMID 10194355. doi:10.1021/bi982900m.
^ ^а ^б Smith, F D; Oxford G S; Milgram S L (1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein”. J. Biol. Chem. UNITED STATES. 274 (28): 19894—900. ISSN 0021-9258. PMID 10391935. doi:10.1074/jbc.274.28.19894.
^ Vivo, M; Calogero R A; et al. (2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein”. J. Biol. Chem. United States. 276 (17): 14161—9. ISSN 0021-9258. PMID 11278317. doi:10.1074/jbc.M006845200.
^ Buchsbaum, Rachel J; Connolly Beth A; Feig Larry A (2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin”. J. Biol. Chem. United States. 278 (21): 18833—41. ISSN 0021-9258. PMID 12531897. doi:10.1074/jbc.M207876200.
^ Terry-Lorenzo, Ryan T; Elliot Elizabeth; et al. (2002). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton”. J. Biol. Chem. United States. 277 (48): 46535—43. ISSN 0021-9258. PMID 12270929. doi:10.1074/jbc.M206960200.

Literatura

Burnett PE; Blackshaw S; Lai MM; et al. (1998). „Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton”. Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8351—6. PMC 20979 . PMID 9653190. doi:10.1073/pnas.95.14.8351.
Hsieh-Wilson LC; Allen PB; Watanabe T; et al. (1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1”. Biochemistry. 38 (14): 4365—73. PMID 10194355. doi:10.1021/bi982900m.
Smith FD, Oxford GS, Milgram SL (1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein”. J. Biol. Chem. 274 (28): 19894—900. PMID 10391935. doi:10.1074/jbc.274.28.19894.
Stephens DJ, Banting G (1999). „Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin”. J. Biol. Chem. 274 (42): 30080—6. PMID 10514494. doi:10.1074/jbc.274.42.30080.
Richman JG; Brady AE; Wang Q; et al. (2001). „Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin”. J. Biol. Chem. 276 (18): 15003—8. PMID 11154706. doi:10.1074/jbc.M011679200.
Vivo M; Calogero RA; Sansone F; et al. (2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein”. J. Biol. Chem. 276 (17): 14161—9. PMID 11278317. doi:10.1074/jbc.M006845200.
Grossman SD; Hsieh-Wilson LC; Allen PB; et al. (2003). „The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines”. Neuromolecular Med. 2 (1): 61—9. PMID 12230305. doi:10.1385/NMM:2:1:61.
Terry-Lorenzo RT; Elliot E; Weiser DC; et al. (2003). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton”. J. Biol. Chem. 277 (48): 46535—43. PMID 12270929. doi:10.1074/jbc.M206960200.
Hsieh-Wilson LC; Benfenati F; Snyder GL; et al. (2003). „Phosphorylation of spinophilin modulates its interaction with actin filaments”. J. Biol. Chem. 278 (2): 1186—94. PMID 12417592. doi:10.1074/jbc.M205754200.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Buchsbaum RJ, Connolly BA, Feig LA (2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin”. J. Biol. Chem. 278 (21): 18833—41. PMID 12531897. doi:10.1074/jbc.M207876200.
Tsukada M, Prokscha A, Oldekamp J, Eichele G (2004). „Identification of neurabin II as a novel doublecortin interacting protein”. Mech. Dev. 120 (9): 1033—43. PMID 14550532. doi:10.1016/S0925-4773(03)00177-1.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Law AJ; Weickert CS; Hyde TM; et al. (2004). „Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines”. The American journal of psychiatry. 161 (10): 1848—55. PMID 15465982. doi:10.1176/appi.ajp.161.10.1848.