RBPJ |
---|
|
Наявні структури |
---|
PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2F8X, 3NBN, 3V79 | | |
Ідентифікатори |
---|
Символи | RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1 |
---|
Зовнішні ІД | OMIM: 147183 MGI: 96522 HomoloGene: 7511 GeneCards: RBPJ |
---|
|
Пов'язані генетичні захворювання |
---|
синдром Адамса—Олівера[1] |
Онтологія гена |
---|
Молекулярна функція | • protein N-terminus binding • GO:0001948, GO:0016582 protein binding • DNA strand exchange activity • chromatin binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
---|
Клітинна компонента | • ядерце • MAML1-RBP-Jkappa- ICN1 complex • transcription regulator complex • цитоплазма • клітинне ядро • нуклеоплазма • transcription repressor complex |
---|
Біологічний процес | • artery morphogenesis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • neuron differentiation • epidermal cell fate specification • positive regulation of cell population proliferation • club cell differentiation • somatic stem cell population maintenance • endocardium development • cell fate commitment • DNA recombination • somitogenesis • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • defense response to bacterium • regulation of timing of cell differentiation • GO:0009373 regulation of transcription, DNA-templated • humoral immune response • keratinocyte differentiation • hair follicle maturation • negative regulation of cell population proliferation • pituitary gland development • negative regulation of cell differentiation • Notch signaling involved in heart development • transcription, DNA-templated • GO:1901313 positive regulation of gene expression • arterial endothelial cell fate commitment • myeloid dendritic cell differentiation • blood vessel remodeling • secondary heart field specification • regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription initiation from RNA polymerase II promoter • sebaceous gland development • positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • inflammatory response to antigenic stimulus • heart development • auditory receptor cell fate commitment • B cell differentiation • регуляція експресії генів • Сигнальний шлях Notch • dorsal aorta morphogenesis • atrioventricular canal development • positive regulation of ephrin receptor signaling pathway • epithelial to mesenchymal transition involved in endocardial cushion formation • outflow tract morphogenesis • cardiac left ventricle morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • labyrinthine layer blood vessel development • blood vessel lumenization • endocardium morphogenesis • ventricular trabecula myocardium morphogenesis • negative regulation of ossification • positive regulation of cell proliferation involved in heart morphogenesis • positive regulation of cardiac muscle cell proliferation • Ангіогенез • Епітеліально-мезенхімальний перехід • positive regulation of BMP signaling pathway • positive regulation of ERBB signaling pathway • blood vessel endothelial cell fate specification • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of transcription of Notch receptor target • positive regulation of Notch signaling pathway • кровотворення • aortic valve development • pulmonary valve development • ventricular septum morphogenesis • negative regulation of cold-induced thermogenesis |
---|
Джерела:Amigo / QuickGO | |
Шаблон експресії |
---|
|
Більше даних |
Ортологи |
---|
Види | Людина | Миша |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (мРНК) | NM_005349 NM_015874 NM_203283 NM_203284 NM_001363577
| NM_001374400 NM_001374401 NM_001374402 NM_001374403 NM_001379406 NM_001379407 NM_001379408 NM_001379409 |
| | NM_001080927 NM_001080928 NM_001277116 NM_009035 NM_001359152 |
|
---|
RefSeq (білок) | NP_005340 NP_056958 NP_976028 NP_976029 NP_001350506
| NP_001361329 NP_001361330 NP_001361331 NP_001361332 NP_001366335 NP_001366336 NP_001366337 NP_001366338 |
| | NP_001074396 NP_001074397 NP_001264045 NP_033061 NP_001346081 |
|
---|
Локус (UCSC) | Хр. 4: 26.16 – 26.44 Mb | Хр. 5: 53.62 – 53.81 Mb |
---|
PubMed search | [2] | [3] |
---|
Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
|