DDX58 |
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已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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2LWD、2LWE、2QFB、2QFD、2RMJ、2YKG、3LRN、3LRR、3NCU、3OG8、3ZD6、3ZD7、4AY2、4BPB、4NQK、4ON9、4P4H、5E3H、5F98、5F9F、5F9H |
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識別號 |
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别名 | DDX58;, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIGI, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1 |
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外部ID | OMIM:609631 MGI:2442858 HomoloGene:32215 GeneCards:DDX58 |
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基因位置(小鼠) |
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| 染色体 | 小鼠4号染色体[2] |
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| 基因座 | 4|4 A5 | 起始 | 40,203,773 bp[2] |
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终止 | 40,239,828 bp[2] |
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RNA表达模式 |
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查阅更多表达数据 |
基因本體 |
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分子功能 | • 核苷酸結合 • helicase activity • 鋅離子結合 • 金屬離子結合 • 血浆蛋白结合 • single-stranded RNA binding • 相同蛋白质结合 • RNA binding • double-stranded RNA binding • double-stranded DNA binding • 水解酶活性 • ATP結合 • nucleic acid binding • 泛素蛋白连接酶结合
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細胞組分 | • 細胞質 • cell projection • 膜 • 双细胞紧密连接 • 细胞膜 • ruffle membrane • 细胞连接 • actin cytoskeleton • 细胞骨架 • 细胞质基质
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生物學過程 | • regulation of cell migration • response to exogenous dsRNA • positive regulation of interferon-alpha production • immune system process • response to virus • cytoplasmic pattern recognition receptor signaling pathway in response to virus • positive regulation of gene expression • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • negative regulation of type I interferon production • detection of virus • viral process • 先天免疫系統 • positive regulation of transcription by RNA polymerase II • RIG-I signaling pathway • regulation of type III interferon production • positive regulation of defense response to virus by host • positive regulation of interferon-beta production • protein deubiquitination • positive regulation of response to cytokine stimulus • cellular response to exogenous dsRNA • defense response to virus • positive regulation of DNA-binding transcription factor activity • positive regulation of myeloid dendritic cell cytokine production
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 9: 32.46 – 32.53 Mb | Chr 4: 40.2 – 40.24 Mb |
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PubMed查找 | [3] | [4] |
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維基數據 |
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