DICER酶 |
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已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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2EB1、4NGB、4NGC、4NGD、4NGF、4NGG、4NH3、4NH5、4NH6、4NHA、4WYQ |
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識別號 |
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别名 | DICER1;, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW |
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外部ID | OMIM:606241 MGI:2177178 HomoloGene:13251 GeneCards:DICER1 |
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相關疾病 |
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胸膜肺母細胞瘤、胚胎性横纹肌肉瘤、DICER1 syndrome、familial multinodular goiter[1] |
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基因位置(小鼠) |
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| 染色体 | 小鼠12号染色体[3] |
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| 基因座 | 12 E|12 54.83 cM | 起始 | 104,654,001 bp[3] |
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终止 | 104,718,211 bp[3] |
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基因本體 |
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分子功能 | • 核苷酸結合 • helicase activity • protein domain specific binding • pre-miRNA binding • 金屬離子結合 • endoribonuclease activity • endoribonuclease activity, producing 5'-phosphomonoesters • 血浆蛋白结合 • siRNA binding • RNA binding • nuclease activity • double-stranded RNA binding • endonuclease activity • 水解酶活性 • ATP結合 • ribonuclease III activity • DNA结合 • deoxyribonuclease I activity
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細胞組分 | • 細胞質 • 细胞质基质 • RNA誘導沉默複合體 • 生长锥 • ARC complex • RISC-loading complex • 轴突 • 树突 • 细胞核 • endoplasmic reticulum-Golgi intermediate compartment • 外排體
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生物學過程 | • neuron projection morphogenesis • RNA processing • negative regulation of transcription by RNA polymerase II • peripheral nervous system myelin formation • pre-miRNA processing • positive regulation of myelination • nerve development • RNA phosphodiester bond hydrolysis, endonucleolytic • positive regulation of Schwann cell differentiation • negative regulation of Schwann cell proliferation • production of miRNAs involved in gene silencing by miRNA • miRNA metabolic process • production of siRNA involved in RNA interference • 基因沉默 • apoptotic DNA fragmentation • 腫瘤壞死因子產生的負調控 • NIK/NF-kappaB signaling • negative regulation of gene expression • tube formation
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | |
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NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438 |
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蛋白序列 | |
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NP_001182502 NP_001258211 NP_001278557 NP_085124 NP_803187 |
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基因位置(UCSC) | Chr 14: 95.09 – 95.16 Mb | Chr 12: 104.65 – 104.72 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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