3-oxoadipyl-CoA thiolase

In enzymology, a 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + acetyl-CoA ${\displaystyle \rightleftharpoons }$ CoA + 3-oxoadipyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and acetyl-CoA, whereas its two products are CoA and 3-oxoadipyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:acetyl-CoA C-succinyltransferase. This enzyme participates in benzoate degradation via hydroxylation.

3-Oxoadipyl-CoA thiolase belongs to the thiolase family of enzymes.

References

• Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W (2002). "Degradation of Aromatics and Chloroaromatics by Pseudomonas sp. Strain B13: Purification and Characterization of 3-Oxoadipate:Succinyl-Coenzyme A (CoA) Transferase and 3-Oxoadipyl-CoA Thiolase". J. Bacteriol. 184 (1): 207–15. doi:10.1128/JB.184.1.207-215.2002. PMC 134768. PMID 11741862.
• Gobel M, Kassel-Cati K, Schmidt E, Reineke W (2002). "Degradation of Aromatics and Chloroaromatics by Pseudomonas sp. Strain B13: Cloning, Characterization, and Analysis of Sequences Encoding 3-Oxoadipate:Succinyl-Coenzyme A (CoA) Transferase and 3-Oxoadipyl-CoA Thiolase". J. Bacteriol. 184 (1): 216–23. doi:10.1128/JB.184.1.216-223.2002. PMC 134769. PMID 11741863.