5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid
Names
Preferred IUPAC name
5,7-Dichloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Identifiers
CAS Number
  • 131123-76-7 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 1714 ☒N
IUPHAR/BPS
  • 2361
PubChem CID
  • 1779
UNII
  • T61ORK73PY checkY
CompTox Dashboard (EPA)
  • DTXSID80893710 Edit this at Wikidata
InChI
  • InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16) ☒N
    Key: BGKFPRIGXAVYNX-UHFFFAOYSA-N ☒N
  • InChI=1/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
    Key: BGKFPRIGXAVYNX-UHFFFAOYAD
  • C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl
Properties
Chemical formula
 C10H5Cl2NO3
Molar mass 258.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

5,7-Dichlorokynurenic acid (DCKA) is a selective NMDA receptor antagonist acting at the glycine site of the NMDA receptor complex.[1]

See also

  • 7-Chlorokynurenic acid
  • Kynurenic acid

References

  1. ^ McNamara D, Smith EC, Calligaro DO, O'Malley PJ, McQuaid LA, Dingledine R. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neuroscience Letters. 1990 Nov 27;120(1):17-20. PMID 2149877
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Ionotropic glutamate receptor modulators
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
  • See also: Receptor/signaling modulators
  • Metabotropic glutamate receptor modulators
  • Glutamate metabolism/transport modulators
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