Milacemide
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| Names | |
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| IUPAC name N2-Pentylglycinamide | |
| Systematic IUPAC name 2-(Pentylamino)acetamide[1] | |
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| MeSH | milacemide |
PubChem CID |
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InChI
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| Properties | |
Chemical formula | C7H16N2O |
| Molar mass | 144.218 g·mol−1 |
| log P | 0.754 |
| Related compounds | |
Related compounds | Tricine |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references | |
Chemical compound
Milacemide (INN)[2] is an MAO-B inhibitor and glycine prodrug.[3] It has been studied for its effects on human memory and as a potential treatment for the symptoms of Alzheimer's disease.[4] Early clinical trials did not show positive results however,[3] and the drug is now abandoned and it is sold as a nonprescription drug or supplement. While milacemide is not an amino-acid, it acts similarly to glycine in the brain.[5]
References
- ^ "milacemide - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 8 August 2005. Identifiers and Related Records. Retrieved 9 January 2012.
- ^ "International Nonproprietary Names for Pharmaceutical Substances. Supplement to WHO Chronicle, 1983, Vol. 37, No. 6 (December). Recommended International Nonproprietary Names (Rec. INN): List 23" (PDF). World Health Organization. p. 6. Retrieved 8 January 2016.
- ^ a b Dysken, MW; Mendels, J; LeWitt, P; Reisberg, B; Pomara, N; Wood, J; Skare, S; Fakouhi, JD; Herting, RL (May 1992). "Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type". Journal of the American Geriatrics Society. 40 (5): 503–6. doi:10.1111/j.1532-5415.1992.tb02019.x. PMID 1634705. S2CID 34816755.
- ^ Harris, Carol Turkington ; foreword by Joseph R. (2002). The encyclopedia of the brain and brain disorders (2nd ed.). New York, NY: Facts on File. ISBN 0-8160-4774-X. Archived from the original on 2014-03-03. Retrieved 2017-09-10.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ Theodore I. Lidsky and Jay S. Schneider Phd, Brain Candy (2001). Brain Candy. New York, United States Of America: Simon & Schuster. ISBN 9780743218436.
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(dopamine, epinephrine,
norepinephrine)
| PAHTooltip Phenylalanine hydroxylase |
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| THTooltip Tyrosine hydroxylase |
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| DBHTooltip Dopamine beta-monooxygenase |
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| PNMTTooltip Phenylethanolamine N-methyltransferase |
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| COMTTooltip Catechol-O-methyl transferase |
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(serotonin, melatonin)
| TPHTooltip Tryptophan hydroxylase |
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| AANATTooltip Serotonin N-acetyl transferase |
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| ASMTTooltip Acetylserotonin O-methyltransferase |
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| HDCTooltip Histidine decarboxylase |
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| HNMTTooltip Histamine N-methyltransferase |
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| DAOTooltip Diamine oxidase |
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See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins
 | This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
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