Aloe emodin

Chemical compound
  • None
Identifiers
  • 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
CAS Number
  • 481-72-1 ☒N
PubChem CID
  • 10207
ChemSpider
  • 9792 checkY
UNII
  • C8IYT9CR7C
KEGG
  • C10294 checkY
ChEBI
  • CHEBI:2607 ☒N
ChEMBL
  • ChEMBL40275 checkY
CompTox Dashboard (EPA)
  • DTXSID2030695 Edit this at Wikidata
ECHA InfoCard100.006.884 Edit this at WikidataChemical and physical dataFormulaC15H10O5Molar mass270.240 g·mol−13D model (JSmol)
  • Interactive image
Melting point223 to 224 °C (433 to 435 °F) Sublimes in CO2 stream
  • O=C2c1cccc(O)c1C(=O)c3c2cc(cc3O)CO
InChI
  • InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 checkY
  • Key:YDQWDHRMZQUTBA-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Aloe emodin (1,8-dihydroxy-3-(hydroxymethyl)anthraquinone) is an anthraquinone and an isomer of emodin present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action.[1] Aloe emodin is not carcinogenic when applied to the skin, although it may increase the carcinogenicity of some kinds of radiation.[2][3]

Aloe emodin is found in the gel, sap or leaves of aloe vera, the socotrine aloe, Barbados aloe, and Zanzibar aloes, the bark of Frangula (Rhamnus frangula) and cascara sagrada (Rhamnus purshiana), the leaves of Senna (Cassia angustifolia), and the rhizome of rhubarb (Rheum rhaponticum).[citation needed] Aloe-emodin has not been found in Natal aloes.[citation needed]

References

  1. ^ The Merck Index (12th ed.). p. 313.
  2. ^ Badgwell DB, Walker CM, Baker WT, Strickland FM (March 2004). "Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors". Molecular Carcinogenesis. 39 (3): 127–38. doi:10.1002/mc.10170. PMID 14991742. S2CID 24146785.
  3. ^ National Toxicology Program (September 2010). "Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study)". National Toxicology Program Technical Report Series (553): 7–33, 35–97, 99-103 passim. PMID 21031007.

See also